A general strategy to target cells by nanoparticles for drug delivery, imaging, or diagnostics involves immunospecific binding between the probes and target molecules on the particles and on the cell surface, respectively. Usually, the macromolecular nature of the molecules requires a specific conformation to achieve the desired immunospecificity, and the extent of deposition of particles is limited by the number of receptor molecules present on the cell. In this report, we successfully obtain targeted binding by decorating the nanoparticle with simple ions, such as Ca(2+), without affecting the cell's vitality. The yeast cells for study, Saccharomyces cerevisiae, have no specific electrostatic affinity toward positive charge as confirmed by lysine-coated Au nanoparticles. The specificity of nanoparticle binding is found to be directly related to the metabolic vitality of the yeast cell (i.e., a significantly larger deposition occurs on a younger generation with higher metabolism than on older cells). The ion-mediated targeted deposition seems to be a general phenomenon for biologically important ions, as demonstrated by the contrast between Mg(2+) and (toxic) Cd(2+). The high density of (percolating) nanoparticle deposition as a monolayer on the cells, as a result of the large number of ion receptors on the cell surface, is shown to be a potential method for building bioelectronic devices. The use of ions as an interface to target cells can have possible applications in diagnosing diseases and making biosensors using live cells.
The present paper is concerned with the application of the equations of a saturated smooth air-gap machine to the analysis of the transient behavior of a multi-phase (six-phase) self-excited induction generator (SEIG). In the analytical model (d-q axis model), the effects of common mutual leakage inductance between the two three-phase winding sets have been included. A detailed experimental investigation of self-excitation process, loss of excitation and re-excitation, switching-in of pure resistive load without, and with series compensation (short shunt) is also included in this paper.
The dehydrogenative Heck coupling (Fujiwara–Moritani reaction) of unactivated olefins with 3,4‐dihydro‐2H‐pyrans is described. The two main highlights of the work are the use of unconventional unactivated olefins as coupling partners in the palladium‐catalyzed reaction and the use of aprotic conditions for the coupling reaction of the acid‐labile dihydropyrans.magnified image
Solar energy is the primary resource for all biological, chemical and physical processes. The amount of global solar radiation is an important parameter for solar energy applications. It is common to estimate a monthly average of daily global solar radiation using different regression models. These models in turn exploit the correlation between solar radiation and various atmospheric factors. These factors are commonly derived from meteorological, geographical and climatological data that are readily available for majority of weather stations across the world. In this paper, a novel regression model that can predict location-independent daily global solar radiation is presented. The proposed exponential quadratic model captures the correlation between measured global solar radiation values, sunshine hour and Air Pollution Index for Indian cities. In addition to this, an extended study of several other regression models (e.g. linear, quadratic, exp.-linear and exp.-quadratic) is also presented. This analysis with real data from Indian cities suggests that air pollution is a more significant factor than location when predicting solar radiation. Finally, the model parameters (regression coefficients) for each model are listed out. Additionally, the generalised model equation for the best performing model is also presented.
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