Background: Teneligliptin is a DPP-4 inhibitor with unique chemical structure. Efficacy and safety of Teneligliptin is well established in the patients with type 2 diabetes mellitus (T2DM) in different randomized controlled trials. However, limited real-world data is available for Teneligliptin pertaining to Indian T2DM patient profile such as demographics, duration of disease, currently prescribed anti-hyperglycemic drugs, initiation of Teneligliptin as monotherapy or as an add on therapy.Methods: A cross-sectional, multicenter, non-interventional study was conducted to understand the demographics and clinical profile of Indian T2DM patients (n=5091) who were prescribed Teneligliptin.Results: Majority of patients were male (65.2%) with family history of T2DM present in 43.45% of cases. Age at onset of T2DM was 51.1±11.6 years. Among the T2DM patients, 36.2% of patients were newly diagnosed and more than half of them (54.7%) were uncontrolled with current anti-hyperglycemic drugs. Mean HbA1c level among these patients was 8.09±1.3%. Mean fasting and postprandial blood glucose levels were 170.2±46.9 mg/dl and 255.3±69.3 mg/dl respectively. Teneligliptin was prescribed as monotherapy in 2165 (41.66 %) of patients while as dual, triple and quadruple therapy in 2346 (46.08%) and 551 (10.82%) and 29 (0.56%) respectively. Among the patients on current anti-hyperglycemic treatment, most commonly prescribed drugs along with Teneligliptin were metformin (43.39%) followed by glimepiride (11%) and voglibose (3.42%).Conclusions: Teneligliptin is preferred as monotherapy and combination with metformin and sulfonylureas (mostly glimepiride) in newly diagnosed and uncontrolled T2DM patients in Indian scenario.
Chronic Rhinosinusitis is a common disorder, and its prevalence vary from 1-20% globally. The incidence of fungal sinusitis has increased to such extent in recent years that fungal infection is a common diagnosis in patients with Chronic Rhinosinusitis. The objectives of this current research were objectives of estimating the prevalence of Fungal aetiology in chronic sinusitis patients and their drug sensitivity pattern with common antifungal drugs. A total of 61 Cases present with Chronic Rhinosinusitis (CRS), visited in a tertiary care hospital based in Central Delhi, were included in our study. Excision of sinus tissue, including polyps and masses, were collected in the operation theatre during Functional Endoscopic Sinus Surgery (FESS) procedure in a sterile manner. All the tissues brought in sterile normal saline were processed for bacteriological and mycological examination. Tissues, obtained in 10% formalin were processed for histopathological and cytological analysis. A total of 14 (22.9%) cases of Chronic Rhinosinusitis were affected by fungal etiologies. By E test, the MIC range for isolates of Rhizopus arrhizus after 24 hr of incubation was 1-2 μg/mL, and the mean was 1.5 μg/Ml. Similarly, the MIC range for isolates of Aspergillus flavus after 48 hr of incubation was 0.5-16 μg/mL, and the mean was 4.09μg/mL. By the M38-A broth dilution method, the MIC range for the isolates of Rhizopus arrhizus after 24 hr of incubation was 0.5-2 μg/mL, and the mean was 1.25 μg/ml. Similarly, the MIC range for isolates of Aspergillus flavus after 48 hr of incubation was 0.5-4 μg/mL, and the mean was 1.95 μg/mL.
function. To screen the widest possible population, we are obliged to use non-invasive investigation techniques. Methods: Study population of 975 male self-supporting patients, complaining of thoracic pain, divided in 495 healthy subjects (HS) and in 480 coronary patients (CP), subdivided in three age groups: 40-59y; 60-79y; 80-99y. Measurement by speckle-tracking echocardiography "global longitudinal peak systolic strain average (GLPSSavg) of left ventricle, and "average peak longitudinal strain of 5 myocardial segments with the lowest strain values" (Avg5LSS). Maximal exercise tests on the bicycle to measure the percentage of the performed load compared with the calculated maximal expected load (PL/EL). Heart rate variation during exercise test (HR). Sum of maximal left ventricle diameter plus maximal left atrial diameter (LVLA) and E/E'. For statistical analysis Levene's Test, t-test and 95% confidence interval. Results: Decrease of GLPSSavg (p¼0,000) for total group and for all age groups in CP, compared with HS. Similar findings for Avg5LSS. Progressive decrease of PL/EL% with age as well in HS as in CP. For all groups decrease (p¼0,000) of PL/EL % in CP, compared with HS (Table 1). HR during exercise is statistically significant lower in CP. LVLA and E/E' are for all groups significantly higher (p¼0,000) in CP. In a graphic representation with GLPSSavg or Avg5LSS on y-axis and PL/EL%, HR, LVLA or E/E' on x-axis, we observed two independent and totally separated clusters between HS and CP. These findings were confirmed by 95% confidence interval ( Table 2). Conclusions: When in an ambulatory setting after anamnesis and electrocardiography the diagnosis of coronary atherosclerosis remains unresolved, we dispose of six non-invasive parameters to predict underlying ischemic heart disease. Disclosure of Interest: None DeclaredBackground: Newer Oral Anti Platelets, Prasugrel and Ticagrelor are associated with significant reduction in cardiovascular events when compared with Clopidogrel in their respective randomized trials in Acute Coronary Syndrome (ACS) patients. To date no clinical trial directly compared these two drugs. Platelet Reactivity (PR) of antiplatelet drugs correlates with their clinical effects and bleeding. There are published studies comparing both the drugs, however; a systematic analysis is lacking. Method: A systematic literature search of the MEDLINE, EMBASE and COCHRANE databases was performed. Original randomized studies directly comparing platelet reactivity (PR) of Ticagrelor and Prasugrel by Verify Now Assay Method were included and a descriptive statistical analysis was performed. Results: To date five randomized direct comparative PR studies of Ticagrelor and Prasugrel in variety of ACS patients met our criteria for inclusion. Total randomized patients were 798 including those having risk factors like, diabetes mellitus, patients exhibiting High on Treatment Platelet Reactivity (HTPR). PR was measured after either loading or maintenance dose of both the drugs. Individual study analysis...
Background: Dermatophytosis is a disease of hair, nails, and stratum corneum of the skin caused by dermatophytes. The prevalence of dermatophytosis in a geographical area depends on a variety of factors such as climate, personal hygiene, and individual susceptibility. The clinical importance of isolating and identifying dermatophytes is to start appropriate treatment & to detect probable infection sources. Also, identification is important for prognostic consideration. Objectives: Our study aims to know the clinico-mycological profile in suspected cases of dermatophytosis. Patients and Methods: A total of 110 suspected cases of dermatophytoses that were diagnosed clinically by a dermatologist were included in this study. Specimen of skin scrapings, hairs & nail clippings wherever appropriate were collected from these patients. Specimens collected were subjected to standard mycological procedures. Results: In our study, the most common age group affected was 21-30 years (31.82%). The majority of the cases were from the lower middle class (38%). The commonest clinical type was Tinea corporis (48%). In 72.73% of cases, we were able to detect fungi either by direct microscopy and/or culture. Out of 62 culture isolates, T.rubrum was found to be the commonest (59.7%), followed by T.mentagrophytes (24.2%), E.floccosum (6.5%), T.tonsurans (3.2%), M. gypseum (3.2%) and one isolate each of M. audouinii and M. canis. Conclusion: With proper techniques, various species of dermatophytes can be identified. But conventional methods are time-consuming and a week to a month is required for identification to species level. So the development of rapid molecular techniques is the need of the hour.
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