Star Enterprise is a joint venture partnership between en Texaco Inc. and the Saudi Arabian Oil Company. Created in 1988, it became fully operational on January 1, 1989. This new organization inherited staff, facilities, and information resources existing within Texaco Inc. at the time of formation. A significant opportunity for the new organization was to create a new Enterprise Information Technology Architecture to support business functions and management decision making. While this venture was an opportunity, it was also a challenge because of the existing information technology that was comprised of incompatible hardware and nonintegrated systems. This paper describes the architecture that emerged and reviews its current status. Two major contributions of the paper are to identify the principles upon which the architecture is being created and to review what has been learned to date in the .process of implementing the architecture.
Peripheral blood mononuclear cells of most normal adults and patients with breast or lung cancer were found to inhibit [3H] thymidine uptake by lymphoid cell lines in a growth inhibition assay. At effector:target cell ratios between 5:1 and 20:1, lung cancer patients and breast cancer patients, when compared to normal individuals, demonstrated significantly greater inhibition of [3H] thymidine uptake by a human lymphoid cell line (F-265). The effector cells were adherent and were probably monocytes. Sephadex G-10 column passage or adherence to plastic removed most growth-inhibitory activity. Adherent cells recovered from plastic flasks (88-94% monocytes) were strongly growth-inhibitory. Lung cancer patients receiving BCG immunotherapy were found to have an apparently increased activity compared to patients not treated with BCG. The possible mediation of the growth inhibition by release of prostaglandins was suggested by the reduced cytostatic effects in the presence of indomethacin. Growth-inhibitory activity was not species-restricted, since human effector cells and also effector cells from tumor-bearing mice were reactive against the human target cell and against a murine lymphoma line (RBL-5). Natural killer (NK) cells did not appear to contribute appreciably to the observed cytostasis, since the levels of their activities did not correlate, and human NK cells are non-adherent and have little reactivity against F-265 or RBL-5. The inhibition of [3H]thymidine uptake by target cells was demonstrated to be a good reflection of actual inhibition of proliferation, since incubation of adherent cells from cancer patients with F-265 resulted in similar degrees of reduction in the number of target cells and in [3H] thymidine uptake.
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