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Nanotechnology is thriving these days and plays a great role in the expansion of biosensors. A range of nanomaterials are used in the growth of biosensors in order to boost the performance and sensitivity of biosensors. Nanomaterials like nanowire, nanoparticles, carbon nanotubes, quantum dots etc. are helpful for increasing different properties like enzyme loading capacity, bioanalyte loading, good absorption as well as immobilization of enzymes. The skill of nanobiosensors becomes extra accurate and reliable as it allows quick selection of diverse analytes at little cost. The main target for nanobiosensor research includes the development of novel technologies in order to make improvements in the field of marker detection of human and animal disease, identification and study of therapeutic compounds, characterization of nano and bio materials and the development of biocatalysts. This paper has reviewed basic principles and various nano-structure based biosensors along with their applications in different areas such as biomedical and forensic, environmental, agricultural and the food sector and recent advancements.

: Basal cell carcinoma (BCC) is a slow growing, locally destructive, malignant tumor of the skin. It is derived from non- keratinizing cells that originate from the basal layer of the epidermis. After excision nasolabial flap, median forehead dorsal nasal flap, glabellar flaps, bilobed flaps, cheek and craniofacial flaps are used for nasal reconstruction. The Zitelli’s bilobed flap is one of the most useful flaps for nasal reconstruction. It is a simple double transposition flap and is designed to move more skin, without deformation. A 60-years old male patient reported to our department with complains of circular raised and reddish discoloration lesion on the left side of the nose. Surgical excision and reconstruction of defect using bilobed flap was planned under general anaesthesia. The flap was designed in such a manner that the flap could be turned over the defect on the ala of the nose and closure of the donor site could be done primarily without deformity. Surgical excision of the nose lesion was done and reconstruction was performed using bilobed flap. The patient has been followed up for 1year with no evidence of recurrence. The bilobed flap is a versatile and reliable flap for coverage of small skin and soft tissue defects of the lower third of the nose. It gives a successful outcome if it is designed well and performed properly. In this case it helped us to achieve a defect free cosmetically fine nose after excision of basal cell carcinoma nose.

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