Spectral data of coumarin isoxazoline derivatives 11a-d.
Spectral data of coumarin isoxazoline derivatives 12a-d.1 H NMR , 13 C NMR, Mass and Elemental analysis Spectra of compound 11a.1 H NMR , 13 C NMR, Mass and Elemental analysis Spectra of compound 12a.
A highly efficient and milder protocol for the syntheses of novel series of 2-aminothiazoles bearing 5-methylisoxazoline and pyridine-piperazine hybrid molecules has been developed. The target compounds 13a-e were screened for their in vitro cytotoxicity activity against various tumor cell lines including MCF-7 (human breast adenocarcinoma), HCT-116 (colorectal carcinoma), Jurkat (human Tcell leukemia) and THP-1 (human acute monocytic leukemia). The bioactive assay showed most of the new compounds exhibited promising results in comparison with the parental Sunitinib. The synthesized compounds could well be used in the future as lead anticancer drugs in drug development studies. The synthesized compounds were fully characterized by IR, 1 H NMR, 13 C NMR, elemental analysis and mass spectral data.
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