Fluorinated compounds act as a link between synthetic organic chemistry and medicinal chemistry and compel researchers to explore modified and innovative methods for the syntheses of fluorinated motifs. The identification of reliable and efficient methods for the fluorination of organic moieties remains a major challenge in synthetic organic chemistry. Nucleophilic fluorination reactions using a combination of potassium fluoride (KF) and various catalysts or promoters emerged as a viable strategy and provided access to versatile organofluorine compounds. This review will emphasize recent advancements in nucleophilic fluorination reactions using KF: aliphatic nucleophilic fluorination, aromatic nucleophilic fluorination, and heteroatomic nucleophilic fluorination with ionic liquids, modified crown ethers, and transition metal‐catalysts in various protic and aprotic media.
Pyrazole derivatives R 0180Synthesis of Some Novel Ethoxyphthalimide Derivatives of Pyrazolo[3,4-c]pyrazoles. -The synthesis of novel substances containing both a pyrazoline and an ethoxyphthalimide framework as potential pharmacophores is described. -(SHARMA, C.; THADHANEY, B.; PEMAWAT, G.; TALESARA*, G. L.; Indian J.
Fused pyridine derivatives R 0450 Synthesis and Antimicrobial Evaluation of Some Alkoxyphthalimide Derivatives of Naphthyridine. -The majority of the synthesized title compounds (IX) and (XI) show moderate to strong antimicrobial activity. -(BHAMBI, D.; SALVI, V. K.; BAPNA, A.; PEMAWAT, G.; TALESARA*, G. L.; Indian J. Chem., Sect. B: Org.
Activity. -The antibacterial activity of title compounds is weak. The chlorophenyl derivatives (VIId) and (XId) show stronger activity than the other derivatives. -(PEMAWAT, G.; TALESARA*, G. L.; Indian J.
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