Thiazole derivatives R 0260Synthesis and Pharmacological Studies of Some Phthalimidoxy Substituted Spiro-thiazolidinone Derivatives of Isatin. -A variety of title compounds (IX) is synthesized starting from chalcone (I) and evaluated for in vitro antifungal and antibacterial effects. Derivative (IXc) is found to be the most active product. -(BHAMBI, D.; SHARMA, C.; SHARMA, S.; SALVI, V. K.; TALESARA*, G. L.; Indian J.
Fused pyridine derivatives R 0450 Synthesis and Antimicrobial Evaluation of Some Alkoxyphthalimide Derivatives of Naphthyridine. -The majority of the synthesized title compounds (IX) and (XI) show moderate to strong antimicrobial activity. -(BHAMBI, D.; SALVI, V. K.; BAPNA, A.; PEMAWAT, G.; TALESARA*, G. L.; Indian J. Chem., Sect. B: Org.
A simple method for the synthesis of title compounds is reported, which were isolated from a series of reactions. After a nucleophilic reaction of 2-phenyl-3,1-benzoxazin-4(3H)-one (1) with thiosemicarbazide to furnish quinazolinylthiourea (2), followed by cyclisation with chloroacetic acid, 3-[(4-oxo-1,3-thiazolidin-2-yliden)amino]-2-phenylquinazolin-4(3H)-one (3) was yielded, which was converted to corresponding arylidene derivatives (5a-f) by treatment with various aldehydes (4a-f). Subsequent condensation of (5a-f) with phthalimidoxyethylbromide gave title compounds (7a-f). The structure of isolated compounds has been determined by means of IR, 1 H NMR and mass spectroscopy.
Arylamines on diazotization and further treatment with dicyandiamide yielded aryldicyandiamide (1a-d), which on addition with aminoxy compound (2) gave corresponding biguanides (3a-d). Cycloaddition of biguanide with ethylchloroacetate furnished 2,4,6-trisubstituted-s-triazines (4a-d). Subsequent treatment of these compounds with N-hydroxyphthalimide or N-hydroxysuccinimide in presence of triethylamine gave final compounds (5a-h). IR, 1 H NMR and mass spectra were used to confirm their structure. Compounds (5a-h) were screened for antibacterial (Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae, Pseudomonas aureus and Staphylococcus aureus) and antifungal (Candida albicans and Aspergillus fumigatus) activities. Antibacterial activity revealed that compounds 5a, 5b, 5c, 5g showed comparable activity against bacteria P. vulgaris, P. aureus, where rest of the compounds showed weak activity against all the pathogenic bacteria. The fungicidal data indicated that compound 5d possess high level activity and rest of the compounds showed comparable to the standard. In the present communication, a series of 2-(2',4'-MATERIALS AND METHODS dinitroarylaminoxy)-4-methoxyphthalimido or methoxysucc inimido-6-(4"-subs.anilino)-s-triazine (5a-h) have been Melting points of synthesized compounds were synthesized and tested for antimicrobial activities. The determined in open capillary tubes and are therefore synthesis of s-triazine 1 and their pharmacological uncorrected. The structures of compounds were are well documented. Some 2-arylamino-4established on the basis of elemental analysis and spectral chloro-6-(pyrimidine-4-carboxyhydrazino)-1,3,5-triazines data. The IR spectra were recorded in the range of 4000 have been synthesized 6 and observed to possess 450 cm-1 using KBr pellets on a FTIR RXI Perkin-Elmer remarkable antitubercular activity. Several derivatives of sspectrophotometer. 1 H NMR spectra were recorded on a triazine show antimicrobial 7 , antibacterial 8 and herbicidal 9 Bruker DRX 300 MHz spectrophotometer using CDCl activities. These are also used for treatment of HIV DMSO-d 6 as solvent. The FAB mass spectra were infection 10. Phthalimidoxy derivatives represent one of the recorded on a Jeol SX-102/DA-6000 spectrometer data
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.