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During the last one and half decades, chemists within vastly different areas of science have witnessed a rising interest in chemical matters incorporating the sulfonimidamide functional group. New synthetic routes to sulfonimidamides have been reported, and the utility of these products has been demonstrated in synthetic, medicinal, agrochemical, and material science applications. In this review, we described the synthesis of sulfonimidamide and their applications in synthetic organic chemistry.magnified image

Propargylamines are an important class of organic compounds that have been widely used as building blocks for the synthesis of various kinds of chemically and biologically relevant compounds. Over the last few years, there have been a rapid growth in the research dedicated to developing the synthetic protocol for propargylamine derivatives. Among various methods that are reported for the synthesis of propargylamines, the three‐component coupling of aldehyde, amine and alkyne (commonly termed as A3 coupling reactions) secured a special place because of its convenient/atom economical approach and thus broadly used by researchers. Our aim in this review is to highlight the most recent advancement on A3 coupling reactions for the synthesis of various propargylamine derivatives as well as on the developments of subsequent transformation of these compounds to useful heterocyclic compounds and the related products.

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Utilization of the fascinating properties of b-oxodithioesters as building blocks in heterocyclic frameworks was started a few decades ago. Its similarity and dissimilarity with b-ketoesters in terms of its synthesis or as a substrate towards synthesis makes it an interesting and emerging field of synthetic organic chemistry.Tuning of catalysts and counter substrates towards selective utilization of its multiple reacting sites was summarized in the following discussion. A diverse range of monocyclic and polycyclic heterocycles with several different heteroatoms is plotted in an easy and reader friendly manner.

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An efficient and highly convergent route to dihydropyrimidinones (DHPMs) and hitherto unreported dihydropyridopyrimidinones has been developed by one-pot, three-component cyclocondensation of aromatic aldehydes, β-oxodithioesters, and urea/6-amino-1,3-dimethyluracil in the presence of recyclable SiO2-H2SO4. On the other hand, salicylaldehyde, β-oxodithioester, and urea reacted under similar conditions to afford the 3-aroyl/heteroaroyl-2H-chromen-2-thiones in high yields instead of Biginelli product. The attractive feature of this approach is the synthesis of three important bioactive heterocyclic frameworks from the same β-oxodithioester under the similar reaction conditions, making this new strategy highly useful in diversity-oriented synthesis (DOS).