Antibiotic-resistant pathogens are
a serious threat to global public
health. The emergence of drug-resistant pathogens is due to the improper
use of antibiotics, making the treatment of bacterial infections very
challenging. Here, we reported an efficient antibiotic delivery nanoparticle
to minimize antibiotic resistance. The nanoparticle was designed to
target the bacterial membrane using mesoporous silica nanoparticles
(MSNs) modified with an ovotransferrin-derived antimicrobial peptide
(OVTp12), enabling the antibiotic to be delivered to the vicinity
of the pathogenic bacteria. Moreover, we observed that OVTp12-modified
nanoparticles effectively inhibited the growth of Escherichia
coli
in vitro and in vivo. The nanoparticle with high biosafety could significantly downregulate
the expression of inflammation-related cytokines in infected tissues.
Thus, this novel bacterial targeted nanoparticle provides advantages
in minimizing bacterial drug resistance and treating bacterial infection.
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