Thalassemia is a condition in which hemoglobin undergoes hemolysis due to impaired synthesis of hemoglobin or globin chains. Growth failure is a common occurrence in patients with thalassemia. Iron overload due to repeated transfusions will cause disturbances in anthropometric status in children with thalassemia. Iron chelation therapy is needed to overcome iron overload in patients with beta-thalassemia major. The level of adherence affects the success of iron chelation therapy. This study aims to determine the relationship between the level of adherence to iron chelation treatment and anthropometric status in patients with thalassemia beta major at Kediri District General Hospital. This type of research is observational analytic with a cross-sectional design. This research was conducted at the SMF Pediatrics (IKA) RSUD Kediri Regency on 16 subjects with B-thalassemia major using a total sampling technique that met the inclusion criteria. The research instruments used in this study were the Morisky Medication Adherence Scale-8 questionnaire and an examination of anthropometric status. The research analysis used the Spearman correlation test. A p-value <0.05 was considered significant. The results showed that there was a significant results between adherence to iron chelation consumption and height for age (p-value = 0.049 > a 0.05), significant results between adherence to iron chelation consumption with weight for age (p-value = 0.036 < a 0.05), and significant results with weight for height (p-value = 0.001 < a 0.05). This study implies that adherence to iron chelation therapy is essential for thalassemia patients. This study shows that patients more adherent to iron chelation treatment have better anthropometric status.
Background. cardiovascular diseases (cvd) are chronic diseases that can be asymptomatic for a long time, and the first symptom may be sudden death. Objectives. This study was designed to draw attention to the frequency of both individual and occupational cardiovascular risk factors and to warn health professionals about variable risk factors. Material and methods. This research was conducted between 01.03.2022-01.09.2022. 160 participants were included in the study. The questionnaire form in which sociodemographic data was asked, the international physical activity questionnaire (short) form and the work stress scale form were directed to the participants. Blood pressure, height, weight and waist circumference were measured, and cvd risks were calculated using the scoRE (systematic coronary Risk Evaluation) 2 cardiovascular risk estimation algorithm. Results. Medium, high and very high cvd risks were determined in 41.8% of the employees. The risk was found to be significantly different among occupational groups (p < 0.001) and economic status (p = 0.036). considering the relationship between shift work status and cvd risk, the risk was found to be significantly higher in those working only during day shifts compared to those working during alternating day and night shifts (p = 0.033). It has been shown that work stress does not increase the cvd risk of healthcare workers (HcW) (p = 0.857). However, it was observed that work stress significantly increases ldl and total cholesterol (p = 0.026 and p = 0.018). Conclusions. In this study, it is emphasised that work-related risks should be taken into consideration, as well as individual cvd risks.
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