The present work aimed to evaluate the possible negative regulation induced by Th2 mechanisms, unleashed by the helminth Haemonchus contortus, on the response by cells of the Th1 profile, important to contain the Corynebacterium pseudotuberculosis cocobacillus infection, in the concomitant ovine infection by these two parasites. For this, the Th1 response was evaluated in two different experimental infection conditions, using the in vitro production of interferon, which is the most typical cytokine of its profile, from cultures of peripheral blood cells of ovine animals co-infected with these two parasites, compared to their production, under the same conditions, in animals only infected with the said bacterium and using as stimulus two antigen preparations with different degrees of purity. The results evidenced a tendency of reduction in the production of this cytokine in the co-infected animals in relation to those infected with Corynebacterium pseudotuberculosis alone, in the two experimental protocols. As for the response by IgG class specific antibodies against this bacterium, evaluated by ELISA and western blot, no differences were observed between groups infected only with bacillus or with double infection.
The ASME PCC-1-2010 Guidelines for Pressure Boundary Bolted Flange Joint Assembly [1] introduced a new method for an appropriate assembly bolt stress determination across bolted flange connections. The method introduced in APPENDIX O of the ASME PCC-1-2010 has recently received substantial attention by several gasket researchers. In this new method, calculation is based in a complex approach that considers the integrity of each joint component. However, almost no information is found about some essential parameters. Therefore, the intent of the present study is to introduce a protocol for the determination of one of these factors: the minimum gasket operating stress (Sgmin-o). This value is defined as “the gasket stress that should be maintained on the gasket during operation in order to assure the leakage does not occur”. This paper will show a detailed study for a protocol to determine the minimum gasket operating stress and actual test results for compressed non-asbestos gaskets. Furthermore, the device used in the research will be defined in detail afterwards.
Na década de 80, o mercado da comunicação no RS foi marcado por apresentar um cenário pouco competitivo, mas com alta demanda pelas organizações. Assim, o cenário acabou exigindo que as agências de publicidade se tornassem mais profissionalizadas. As agências sofreram forte influência do mercado de outras regiões, como RJ e SP. Nesse contexto, a agência de publicidade P&P teve sua trajetória iniciada em 1984 e obteve prêmios que representaram um marco em sua história em relação ao grande e rápido avanço no mercado de atuação. Nos anos 90, a consolidação da empresa foi evidenciada através do reconhecimento como uma das principais agências de publicidade. A partir de 1995, mudanças no contexto educacional aconteceram com o surgimento de cursos de Rádio e TV, Publicidade e Propaganda e Designer Gráfico, demonstrando sinais de novas oportunidades de negócios. O objetivo deste caso de ensino é propor discussão sobre os temas de estratégias organizacionais, empreendedorismo e inovação, no contexto do setor de marketing, considerando as posições e estratégias a serem escolhidas pelos gestores na empresa. Sugerese que seja utilizado em cursos de graduação, em disciplinas de administração estratégica, empreendedorismo, gestão da inovação e comportamento organizacional.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.