A complex formulation for topical treatment, consisting of melatonin, hyaluronic acid, tetracycline, and metronidazole mixture is proposed as periodontal disease adjunctive treatment. In order to follow the structural aspects of the active mixture, spectrophotometric methods: UV-Vis and fluorescence, have been applied. The results obtained complete our previous studies. By adding metronidazole to the mixture composed of: melatonin, hyaluronic acid, and tetracycline, the conjugated effect of the active compounds, combining antimicrobial action with anti-inflammatory and immunomodulatory effect, is expected to significaly improve supportive therapy in moderate forms of periodontitis.
The aim of the present study was to assess the genotoxicity of three different antibacterial, antioxidant and anti-inflammatory mixtures: tetracycline (T) with metronidazole (MZ), melatonin (MEL) with hyaluronic acid (HA), and T+MZ+MEL+HA, in order to choose the best formulation to be used as topic treatment for periodontal disease. In vitro Micronucleus Test was performed (MTvit) according to Organization for Economic Cooperation and Development (OECD) 487 recommendations, in a blind mode, without knowing the composition of the powders evaluated. The highest cytotoxicity and incidence of MN was observed in T+MZ mixture and the mixed compounds T+MZ+MEL+HA, 1 mg/mL in the cell culture, registered the lowest incidence of micronuclei, meaning the lowest cytotoxicity, comparable to the negative control sample. Based on the present findings and previously published results, it can be concluded that the complex mixture T, MZ, MEL and HA showed excellent cytotoxicity profiles, with lower rate of chromosomal damage risk, and therefore, is recommended for safe use as topical treatment in periodontal disease.
In this paper are highlighted the stresses that appear in the peri-implantation area through the forces induced by the masticatory process. The analysis consists of computer modeling of the dental implant and simulation of the load with a distributed force. It is considered a variable direction loading related to the axial insertion of the dental implant, thus simulating an important masticatory process. This type of load reveals stresses developed in the periimplantary bone area, the risk areas where the stresses can cause the appearance of hard tissue damage near the implant and its failure. Increases in stresses up to 159% in the ruminant type of chewing compared with the cutter type are highlighted. An aggravating factor that can lead to implant failure is bruxism that tangentially stresses the implant leading to the concentration of forces at the abutment-implant junction. Conclusions regarding the decrease of stresses at bone-implant junction with up to 23% by a corresponding increase of the implant diameter by 25% are also issued.
Purpose of the study: The aim of the study is to analyze the way the disinfectants embedded in the plaster affect the setting linear dimensional stability, flexural and compressive strength of dental stone models. Material and Methods: Samples were made of type IV dental stone in which different disinfectants had been incorporated (sodium hypochlorite 1%, chlorhexidine 2%) in two concentrations (50%, 100%), thus obtaining four test groups. Mentioned parameters are measured using a micro comparison device and an universal testing machine, analyzing statistically the results in comparison with the control group, prepared by standard indications. Results: Disinfectants cause a decrease of the setting expansion value (ΔL) compared to the standard group in all type of mixing percentage. Variations of compressive and flexural strength are statistically significant, particularly when adding 100% of hypochlorite 1%. Conclusions: Within the limits of this study, replacing the distilled water with disinfectants, alter the value of setting expansion and cause the model dental stone to be brittle in compression and bending.
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