Background: Cutaneous melanoma is the most aggressive form of skin cancer, with the worst prognosis, and it affects a younger population than most cancers. The high metastatic index, in more advanced stages, and the high aggressiveness decrease the effectiveness of currently used therapies, such as surgical removal, radiotherapy, cryotherapy, and chemotherapy, used alone or in combination. Based on these disadvantages, research focused on alternative medicine offers great potential for therapeutic innovation. Medicinal plants represent a remarkable source of compounds for the treatment of various diseases. Methods: In this study, we investigated the tumoral behavior of melanoma under treatment with the compounds baccarin and p-coumaric acid, extracted from green propolis, in mice inoculated with B16F10 cells for 26 days. Results: A significant modulation in the number of inflammatory cells recruited to the tumor region and blood in the groups treated with the compounds was observed. In addition, a significant reduction in the amount of blood vessels and mitosis in the neoplastic area was noticed. Conclusions: Through our research, we confirmed that baccarin and coumaric acid, isolated substances from Brazilian green propolis, have a promising anticarcinogenic potential to be explored for the development of new antitumor agents, adhering to the trend of drugs with greater tolerance and biological effectiveness.
Objetivo: Analisar a incidência e descrever os coeficientes de adultos jovens, 20 a 24 anos, com HIV/AIDS, no período de 2007 a 2017. Métodos: Os dados de notificação foram retirados da base de dados do Sistema de Informações de Agravos de Notificação (SINAN), via Portal de Saúde do SUS (DataSUS). Estes foram tabulados em gráficos no programa Excel, sendo representadas as variáveis: padrões de incidência em cada ano e de maneira comparativa entre os anos, segundo sexo, faixa etária, escolaridade e cor/raça. Resultados: Foram registrados 1124 casos (n=1124) de HIV/AIDS no período de 2007 a 2017 no município de Ribeirão Preto - SP. Na categoria de exposição homens que fazem sexo com homens (HSH), evidenciou de 603 casos (n=603). Em relação a variável de gênero, a população estudada constitui-se em sua maioria de homens 70,37% (n=1102); raça/cor branca, 634 casos (n=634). No que diz respeito à escolaridade, em homens, os resultados demonstraram que em 2007, 27,5% (n=14) apresentavam ensino médio completo e em 2017, 56,2% (n=90). Considerações Finais: Conclui-se que houve um aumento na incidência dos casos de HIV/AIDS em adultos, no período analisado.
Introduction: Currently, an increasing number of studies point to the prevalence of neurological manifestations associated with COVID-19, including stroke. Although the pathophysiology is not completely understood, the infection induces a prothrombotic state stimulate by high levels of factor VIII, fibrinogen and Ddimer. In this sense, high mortality (44,2%) is a challenging context and identify influences of clinical and morphological aspects the outcome of these patients. Design and setting: Literature review conduced in Barão de Mauá University Center, Ribeirão Preto-SP. Objective: Clarifying aspects involved in the pathogenesis and clinical manifestations in patients with COVID-19 and Stroke. Methods: The primary databases utilized to retrieve the salient medical literature presented in this review were Scielo and Pubmed. The search terms, included “stroke”, “SARS-CoV”, “covid-19”. Discussion: Ischemic stroke was the most common subtype found associated with multiple infarctions and cryptogenic etiology. The mechanisms are multifactorial, including conventional pathways stimulated by the pathogen or direct action. Called “sepsis coagulopathy”, activation of the coagulation pathway associated with viral invasion of endothelial cells and excessive release of cytokines causes a prothrombotic state. Hemorrhagic stroke is less common. It is believed that the affinity of SARS-coV- 2 for ACE2 (angiotensinconverting enzyme 2) receptors could directly damage intracranial arteries, causing rupture, associated with fibrinogen depletion and massive release of cytokines and proteases. Conclusion: Individuals affected by COVID-19 that are affected by stroke face more severe conditions and worse associated outcomes. Thus, understanding the pathophysiology and clinical aspects brings greater effectiveness in the care of these individuals and lower mortality.
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