RESUMO: Objetivou-se avaliar as conformidades e não conformidades no preparo e administração de antibacterianos. Estudo observacional e transversal, realizado de agosto a dezembro de 2014 em unidades de clínica médica de um hospital-escola em Fortaleza-Ceará. A amostra foi composta por 265 doses de antibacterianos, que tiveram suas etapas de preparo e administração observadas com dois checklist nos três turnos de trabalho. Os dados foram analisados por estatística descritiva e analítica, e todos os procedimentos éticos foram seguidos. Destaca-se que a não conformidade mais frequente em ambas as etapas foi o cumprimento dos preceitos da semiotécnica 265 (100%). A organização foi associada com o erro na escolha do medicamento (p=0,027), e o uso da prescrição e confirmação do nome do paciente não tiveram relação com os erros (p=0,942). Assim, conclui-se que modificações comportamentais no processo de trabalho precisam ser implementadas para reduzir as não conformidades e consequentemente os erros de medicação. DESCRITORES: Antibióticos; Segurança do paciente; Erros de medicação; Enfermagem; Serviços de enfermagem. CONFORMIDADES E NÃO CONFORMIDADES COMPLIANCE AND NON-COMPLIANCE IN THE PREPARATION AND ADMINISTRATION OF ANTIBACTERIAL DRUGSABSTRACT: The present study aimed to assess compliance and non-compliance in the preparation and administration of antibacterial drugs. Observational and cross-sectional study conducted from August to December 2014 in medical wards of a teaching hospital in Fortaleza-Ceará. The sample was composed by 265 doses of antibacterial drugs whose preparation and administration stages were observed during the three work shifts, with two checklists. Data were analyzed using descriptive statistics, and all ethical procedures were fulfilled. The most frequent non-compliance observed in both stages was compliance withthe requirements of the several techniques performed by nursing professionals (semiotechnique), 265 (100%). The hospital organization was associated with error in the choice of the (p=0.027), and the use of prescription and confirmation of patient's identity were not related to the errors (p=0.942). Thus, it is concluded that behavioral changes in the work process should be implemented to reduce non-compliance and, consequently, medication errors. CUMPLIMIENTO Y INCUMPLIMIENTO EN EL PREPARO Y ADMINISTRACCIÓN DE ANTIBACTERIANOS:IMPLICACIONES PARA LA SEGURIDAD DEL PACIENTE RESUMEN: El presente estudio tuvo como objetivo evaluar el cumplimiento y el incumplimiento en la preparación y administración de fármacos antibacterianos. Estudio observacional y transversal realizado entre agosto y diciembre de 2014 en las alas médicas de un hospital universitario en Fortaleza-Ceará. La muestra fue compuesta por 265 dosis de fármacos antibacterianos cuya etapas del preparación y administración fueron observados durante los tres turnos de trabajo, con dos listas de comprobación. Los datos fueron analizados utilizando estadística descriptiva, y se cumplieron todos los procedimientos éticos. El incu...

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Anxiety disorders are the most prevalent psychiatric disorders being also a comorbid state of other diseases. We aimed to evaluate the anxiolytic-like effects of carvedilol (CVD), a drug used to treat high blood pressure and heart failure with potent antioxidant effects, in animals exposed to chronic unpredictable stress (CUS). To do this, female Swiss mice were exposed to different stressors for 21 days. Between days 15 and 21, the animals received oral CVD (5 or 10 mg/kg) or the antidepressant desvenlafaxine (DVS 10 mg/kg). On the 22nd day, behavioral tests were conducted to evaluate locomotor activity (open field) and anxiety-like alterations (elevated plus-maze—EPM and hole board—HB tests). After behavioral determinations, the animals were euthanized, and the adrenal gland, blood and brain areas, prefrontal cortex (PFC), and hippocampus were removed for biochemical analysis. CUS reduced the crossings while increased rearing and grooming, an effect reversed by both doses of CVD and DVS. CUS decreased the number of entries and permanence time in the open arms of the EPM, while all treatments reversed this effect. CUS reduced the number of head dips in the HB, an effect reversed by CVD. The CUS reduced weight gain, while only CVD5 reversed this effect. A reduction in the cortical layer size of the adrenal gland was observed in stressed animals, which CVD reversed. Increased myeloperoxidase activity (MPO) and interferon-γ (IFN-γ), as well as reduction of interleukin-4 (IL-4) induced by CUS, were reversed by CVD. DVS and CVD increased IL-6 in both brain areas. In the hippocampus, DVS caused an increase in IFN-γ. Our data show that CVD presents an anxiolytic effect partially associated with immune-inflammatory mechanism regulation.

Objectives Sustained stress can cause physiological disruption in crucial systems like the endocrine, autonomic, and central nervous system. In general, skin damages are physical stress present in hospitalized patients. Also, these pressure injuries lead to pathophysiological mechanisms involved in the neurobiology of mood disorders. Here, we aimed to investigate the behavioral alterations, oxidative stress, and corticosterone levels in the brain areas of mice submitted to the model of pressure injury (PI). Methods The male mice behaviors were assessed in the open field test (OFT), elevated plus maze test (EPM), tail suspension test (TST), and sucrose preference test (SPT). Then, we isolated the prefrontal cortex (PFC), hippocampus (HP), and striatum (ST) by brain dissection. The nonprotein sulfhydryl groups (NP-SH) and malondialdehyde (MDA) were measured in the brain, and also the plasma corticosterone levels were verified. Results PI model decreased the locomotor activity of animals (p<0.05). Considering the EPM test, the PI group showed a decrease in the open arm activity (p<0.01), and an increase in the closed arm activity (p<0.05). PI group showed an increment in the immobility time (p<0.001), and reduced sucrose consumption (p<0.0001) compared to the control groups. Regarding the oxidative/nitrosative profile, all brain areas from the PI group exhibited a reduction in the NP-SH levels (p<0.0001–p<0.01), and an increase in the MDA level (p<0.001–p<0.01). Moreover, the PI male mice presented increased levels of plasma corticosterone (p<0.05). Conclusions Our findings suggest that the PI model induces depressive and anxiety-like behaviors. Furthermore, it induces pathophysiological mechanisms like the neurobiology of depression.

RESUMOObjetivo: avaliar a conformidade das práticas de prevenção de infecção de corrente sanguínea relacionada à realização do curativo de cateter venoso central de curta permanência. Método: estudo observacional de 30 enfermeiras na troca do curativo de cateter venoso central de curta permanência em pacientes em um hospital, em Fortaleza-Ce, no período de 2014 a 2015. Para a coleta de dados utilizou-se um check-list. Os dados foram submetidos à análise estatística descritiva. Pesquisa aprovada com Parecer nº 488.788. Resultados: das 30 observações diretas foram registradas 163 não conformidades, sendo as principais relativas à apresentação ao paciente e explicação do procedimento, posicionamento da cabeça, higienização das mãos após o descarte, limpeza das conexões do cateter, identificação do curativo e realização do registro de enfermagem imediato. Conclusão: destacaram-se muitas não conformidades em relação ao procedimento realizado, evidenciando a necessidade de incorporar a prática baseada em evidência científica, de modo a minimizar o risco de infecções em curativo desse dispositivo. Palavras-chave: Enfermagem; terapêutica; prevenção de doenças; cateteres.ABSTRACT Objective: to assess conformity with bloodstream infection prevention practices relating to dressing the short-term central venous catheter. Method: structured observational study of 30 nurses changing dressings on short-term central venous catheters in inpatients at a hospital in Fortaleza, Ceará, from 2014 to 2015. Data were collected using a check-list and subjected to descriptive statistical analysis. The results were displayed as absolute and relative frequencies. The study was approved by Opinion No. 488.788. Results: in 30 direct observations, 163 non-conformities were recorded, relating mostly to: presentation and explanation of the procedure to the patient, positioning of the head, hand hygiene after disposal, cleaning of the catheter connections, identification of the dressing and immediate completion of the nursing record. Conclusion: many nonconformities were found in performance of the procedure, evidencing the need to incorporate scientific evidence-based practice to minimize the risk of infections from dressing this device. Keywords: Nursing, therapeutics, disease prevention; catheters. RESUMENObjetivo: evaluar la conformidad de las prácticas de prevención de infección del torrente sanguíneo relacionadas con la realización del vendaje de catéter venoso central de corta permanencia. Método: estudio observacional de 30 enfermeras durante el cambio de vendaje de catéter venoso central de corta permanencia en pacientes en un hospital de Fortaleza-Ce, de 2014 a 2015. Para la recolección de datos, se utilizó un check-list. Se sometieron los datos al análisis estadístico descriptivo. La investigación fue aprobada bajo el Dictamen nº 488.788. Resultados: de las 30 observaciones directas, se registraron 163 no conformidades, siendo las principales relacionadas a cómo presentar y explicar el procedimiento al paciente, el posicionamiento de ...