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Cited by 9 publications
(3 citation statements)
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“…BDNF, which plays an important role in maintaining brain functions, decreases as oxidative stress increases in cases of mental disorders. In addition to the increase in oxidative stress in the hippocampi of depression model mice, a decrease in the antioxidant activity and BDNF levels have also been reported ( de Sousa et al, 2022 ), which suggests that there is a negative correlation between oxidative stress and BDNF levels. Although a detailed analysis of whether NYT controls oxidative stress in the brain remains necessary, antioxidant activity is thought to be one of the mechanisms by which NYT ameliorates anxiety and depression.…”
Section: Discussionmentioning
confidence: 99%
“…BDNF, which plays an important role in maintaining brain functions, decreases as oxidative stress increases in cases of mental disorders. In addition to the increase in oxidative stress in the hippocampi of depression model mice, a decrease in the antioxidant activity and BDNF levels have also been reported ( de Sousa et al, 2022 ), which suggests that there is a negative correlation between oxidative stress and BDNF levels. Although a detailed analysis of whether NYT controls oxidative stress in the brain remains necessary, antioxidant activity is thought to be one of the mechanisms by which NYT ameliorates anxiety and depression.…”
Section: Discussionmentioning
confidence: 99%
“…Carvedilol is known to have antidepressant effects comparable to those observed for desvenlafaxine, which is a serotonin and norepinephrine reuptake inhibitor. [ 197 ]…”
Section: The Most Well‐studied Multitarget Drugs With Linked Biaromat...mentioning
confidence: 99%
“…Oxidative stress induced by chronic stress can lead to mPFC damage and decreased hippocampal neurogenesis [ 94 ], eventually leading to depression [ 47 , 51 , 55 , 83 , 93 , 94 ] or anxiety-like behavior [ 27 , 50 ]. CUMS exposure also significantly decreased GSH, BDNF, phosphorylation of AKT, and mTOR in PFC [ 50 , 51 , 93 ], and antioxidant drugs such as resveratrol [ 93 ], 5-HT [ 95 ], or carvedilol [ 96 ] can increase BDNF, AKT, and mTOR and decrease oxidative stress, significantly alleviating depression. Stress-induced depression may be also related to oligodendrocyte function in the PFC [ 97 , 98 ]; the increase of oligodendrocytes in PFC can be observed after chronic stress [ 50 ], which may be body compensation [ 99 ].…”
Section: Neurological Links Between Stress and Key Brain Regionsmentioning
confidence: 99%