Background: Acute kidney injury (AKI) is often one component of multiple organ failure (MOF) in the intensive care unit (ICU
Results: Of the 834 critically ill patients, 743 (89%) developed some degree of AKI. Ninetyone percent of the high-risk cohort developed AKI and 87% of the low-risk cohort developed AKI. Patients with AKI had higher mortality at 1 year than patients without AKI (adjusted odds ratio [OR], 2.5; 95% confidence interval, 1.38 to 4.53); P interaction 0.003). Hospital mortality was greater for high-risk patients without AKI than for low-risk patients with AKI.Conclusion: Acute kidney injury occurs at similar frequency in high-and low-risk ICU patients and has significant impact on survival in both groups. Cardiovascular collapse or respiratory failure has greater impact on short term mortality than AKI, but this effect diminishes over time. Conversely, the impact of AKI on mortality increased over time and remained an independent risk factor for mortality.
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