A strategy for the prevention and management of haemorrhage in patients with inhibitors to factor VIII by intensive plasma exchange and human factor VIII infusion is described. The advantages and disadvantages of this approach are discussed in the light of the authors' experience with the technique and the alternative methods of treatment described in the literature.
In this study the immunoperoxidase technique was used to demonstrate the blood group antigens A, B and H in normal gastric mucosa and primary and metastatic gastric carcinomas. No clear relationship between tumour differentiation and preservation of blood group antigens was found. In some well differentiated tumours there was a marked loss of blood group substance, whereas in other poorly differentiated tumours, both primary and metastatic, it was easily detectable. In some tumours an inverse relationship between A or B and H activity was noted. This observation is consistent with the theory that in some malignant cells there is a blocking of the normal step-by-step elongation of the carbohydrate portion of blood group substances.
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