One of the hallmarks of the Berezinskii-Kosterlitz-Thouless (BKT) transition in two-dimensional (2D) superconductors is the universal jump of the superfluid density, that can be indirectly probed via the non-linear exponent of the current-voltage IV characteristics. Here, we compare the experimental measurements of IV characteristics in two cases, namely NbN thin films and SrTiO3-based interfaces. While the former display a paradigmatic example of BKT-like non-linear effects, the latter do not seem to justify a BKT analysis. Rather, the observed IV characteristics can be well reproduced theoretically by modelling the effect of mesoscopic inhomogeneity of the superconducting state. Our results offer an alternative perspective on the spontaneous fragmentation of the superconducting background in confined 2D systems. arXiv:1905.01221v1 [cond-mat.supr-con]

One of the main problems in the development of immunosensors is to overcome the complexity of binding antibody to the sensor surface. Most of immobilizing methods lead to a random orientation of antibodies with a lower binding site density and immunoaffinity. In order to control the orientation of antibody immobilization, several resorc[4]arene derivatives were designed and synthesized. After the spectroscopic characterization of resorc[4]arene self-assembled monolayers (SAMs) onto gold films, the surface coverage and the orientation of insulin antibody (Ab-Ins) were assessed by Surface Plasmon Resonance (SPR) technique and compared with a random immobilization method. Experimental results combined with theoretical studies confirmed the dipole-dipole interaction as an important factor in antibody orientation and demonstrated the importance of the upper rim functionalization of resorcarenes. Accordingly, resorcarene 5 showed a major binding force towards Ab-Ins thanks to the H-bond interactions with the amine protein groups. Based on these findings, the resorcarene-based immunosensor is a powerful system with improved sensitivity providing new insight into sensors development.

In this study, a series of 49 five-membered heterocyclic compounds containing either a pyridine- or a pyrrole-type nitrogen were synthesized and tested against Mycobacterium tuberculosis. Among them, only the 1,3,5-trisubstituted pyrazoles 5–49 exhibited minimum inhibitory concentration values in the low micromolar range, and some also exhibited an improved physicochemical profile without cytotoxic effects. Three pyrazoles were subjected to an animal tuberculosis efficacy model, and compound 6 induced a statistically significant difference in lung bacterial counts compared with untreated mice. Moreover, to determine the target of this series, resistors were generated, and whole genome sequencing revealed mutations in the mmpL3 gene.

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