SYNOPSISThe enzymes phosphohexose isomerase, lactate dehydrogenase, hydroxybutyrate dehydrogenase, isocitric dehydrogenase, glutamate dehydrogenase, and sorbital dehydrogenase were assayed in cases of known carcinoma of the cervix and of carcinoma in situ. Phosphohexose isomerase, lactate dehydrogenase, and isocitric dehydrogenase were also assayed in a number of normal women and in those with benign lesions. It is unlikely that vaginal fluid enzymology will provide a screening test for cervical carcinoma.
Phosphohexose isomerase activity has been studied in a well women's clinic with an automated method. In this series, in which freeze drying was used, the assay was not a reliable screening technique, as it was found that the method caused considerable loss of enzyme activity.
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