Vaginal fluid enzyme patterns in benign and malignant lesions of the female genital tract

Muir, G. G.; Valteris, G.

doi:10.1136/jcp.22.5.593

Cited by 7 publications

(4 citation statements)

References 17 publications

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“…The overall increase in aspirate lactate dehydrogenase activity found among patients with carcinoma in situ (Group A ) over normal patients (Emes et al, 1980) and the further increase with the appearance of clinically invasive carcinomas (Group B) (Table I) is in general agreement with results obtained elsewhere for lactate dehydrogenase and other glycolytic enzymes in vaginal fluid (Lawson and Watkins, 1965;Muir, 1966;Boyd et al, 1967;Stagg and Whyley, 1968;Muir and Valteris, 1969). Among postmenopausal women, any increase in enzyme activity occurring with the appearance of carcinoma in situ was masked by the normal postmenopausal increase in enzyme activity.…”

Section: Discwssionsupporting

confidence: 87%

“…It is of interest that the presence of symptoms suggestive of pelvic disease did not appear to increase aspirate lactate dehydrogenase activity. Other studies have indicated that a raised aspirate enzyme activity may be the result of an inflammatory response (Muir and Valteris, 1969) and, in biopsy material, enzyme levels are increased in certain benign conditions such as chronic cervicitis (Mainigi, 1972), cervical erosion and atrophic vaginitis (Bell and Egerton, 1965).…”

Section: Eflect Of Initial Histology On Lactate Dehydrogenase Activitmentioning

confidence: 99%

“…and in vaginal fluid (Lawson and Watkins, 1965;Muir, 1966;Stagg and Whyley, 1968;Dorrance and Finkle, 1969;Muir and Valteris, 1969), much of this work being directed towards the development of a test for the detection of carcinoma in situ.…”

mentioning

confidence: 99%

“…The assay of lactate dehydrogenase activity in vaginal fluid was rejected for use in screening tests because 25 per cent of normal women shovYed abnormal (false-positive) enzyme levels (Muir and Valteris, 1969). We have recently shown that more than 70 per cent of normal postmenopausal women provide vaginal fluid specimens containing high enzyme levels (Emes et al, 1980), and in the light of this it was decided to reinvestigate the assay of lactate dehydrogenase activity in vaginal fluid and assess its possible diagnostic use in cancer of the cervix.…”

mentioning

confidence: 99%

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The Effect of Carcinoma of the Cervix on the L‐lactate‐nicotinamide‐adeninedinucleotide Oxidoreductase Activity in Vaginal Aspirates

Emes

Latner

Guthrie

et al. 1981

BJOG

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Summary Lactate dehydrogenase (L‐lactate‐NAD+ oxidoreductase; EC 1. 1. 1. 27) has been assayed in saline extracts of vaginal aspirates obtained from patients with carcinoma in situ and from patients with clinically detectable invasive carcinoma of the cervix. Taking premenopausal and postmenopausal patients separately, significant differences were found between the aspirate lactate dehydrogenase activities obtained from patients with carcinoma in situ and the activities obtained from patients with invasive carcinoma; generally higher activities were obtained from the latter. With the exception of postmenopausal patients with carcinoma in situ, aspirate enzyme activities obtained from both groups of patients were significantly different from those obtained from normal women. Significantly higher lactate dehydrogenase activity was found in aspirates from patients for whom histology showed the presence of an adenocarcinoma or certain highly malignant cell types. Treatment by radium insertion usually resulted in a fall in total lactate dehydrogenase activity. Significant differences between patient groups were found for the proportions of single lactate dehydrogenase isoenzymes in a few instances but no significant difference in overall isoenzyme distribution was found.

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Section: Discwssionsupporting

confidence: 87%

Section: Eflect Of Initial Histology On Lactate Dehydrogenase Activitmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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The Effect of Carcinoma of the Cervix on the L‐lactate‐nicotinamide‐adeninedinucleotide Oxidoreductase Activity in Vaginal Aspirates

Emes

Latner

Guthrie

et al. 1981

BJOG

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The role of early diagnosis in controlling large bowel cancer.An overview

Sherlock¹,

Winawer²

1977

Cancer

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Since early diagnosis is essential to improve the cure rate for large bowel cancer, we must use all known investigative tools to make a diagnosis in symptomatic patients in addition to periodic selective investigation of high-risk groups, such a8 those with familial polyposis, inflammatory bowel disease, previous polyps or cancer. However, our goal must be more ambitious than this. If we wait until patients have symptoms of colorectal cancer, the cure rate will significantly decrease. A mass-screening approach, therefore, is needed for the asymptomatic patient. One such approach commences with the testing for occult blood in the stool followed by intensive investigation for the source of bleeding. Newer techniques. now under investigation, such as determination of CEA in colonic washings,.ptterns of enzymes in blood and other.body fluids, fluorescent cytology and tn u i h isotopic surface labeling of colonic cells, may help to identify individuals either harboring an occult neoplasm or at increased risk for the development of colon or rectal cancer. The application of these parameters and the early recognition of precancerous lesions may lead to earlier diagnosis or diagnosis in the incipient stage of disease, which, in turn, should lead to improved survival.

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Cancer in Inflammatory Bowel Disease: Risk Factors and Prospects for Early Detection

Sherlock

Winawer

1978

Gastrointestinal Tract Cancer

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Vaginal fluid enzyme patterns in benign and malignant lesions of the female genital tract

Cited by 7 publications

References 17 publications

The Effect of Carcinoma of the Cervix on the L‐lactate‐nicotinamide‐adeninedinucleotide Oxidoreductase Activity in Vaginal Aspirates

The Effect of Carcinoma of the Cervix on the L‐lactate‐nicotinamide‐adeninedinucleotide Oxidoreductase Activity in Vaginal Aspirates

The role of early diagnosis in controlling large bowel cancer.An overview

Cancer in Inflammatory Bowel Disease: Risk Factors and Prospects for Early Detection

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