The Schiff base derived from 2-sulphanilamidopyridine and 2-hydroxy-3-methoxy benzaldehyde and its metal complexes have been synthesized and characterised by IR, 1 H NMR, UV, elemental analysis, molar conductance and magnetic susceptibility. The Schiff base ligand and the metal complexes were screened for antimicrobial activity by disc diffusion technique. From the analytical and spectral data, the stoichiometry has been found to be 1:2 for all the metal complexes. An octahedral structure has been proposed. All these metal complexes were found to be active against bacteria and fungi.
ABSTRACT. The present study is aimed to synthesise Schiff bases from sulfathiazole/ sulfamethoxazole/ sulfadimidine with 2-hydroxybenzaldehyde. The synthesized Schiff bases were characterized by analytical data, IR, 1H-NMR, 13C-NMR, UV-Vis spectra, mass spectra and screened for antibacterial activity against gram positive bacteria Staphylococcus aureus and gram negative bacteria Salmonella typhiand antifungal activity against Candida albicans and Mucor by disc diffusion method. Zone of inhibition indicated that the Schiff base possessed highly potent antimicrobial activity when compared to sulpha drugs.
KEY WORDS: 4-Amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, 4-amino-N-(5-methylisoxazol-3-yl)-benzenesulfonamide, 4-amino-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide, 2-hydroxybenzaldehyde, antimicrobial activity
Bull. Chem. Soc. Ethiop. 2021, 35(2), 435-448.
DOI: https://dx.doi.org/10.4314/bcse.v35i2.16
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