A new barbiturate has been synthesized from the ethanolic solution of 1-chloro-2,4-dinitrobenzene, barbituric acid, and triethylamine. The structure of the isolated molecule has been confirmed by ultraviolet (UV)-visible (VIS), infrared (IR), proton magnetic resonance (PMR), 13 C nuclear magnetic resonance (NMR), correlation spectroscopy (COSY) and mass spectrometry (MS) spectral studies. Elemental analysis and other qualitative tests have also been carried out to elucidate the proposed structure. The anticonvulsant activity of the synthesized molecule was tested by the maximal electro shock method. Albino rats of either sex weighing 150-200 g were used for the study. The drug was given 1h before the induction of maximal electro shock test. The different stages of convulsions such as tonic flexor, tonic extensor, clonus convulsion, stupor, and recovery/death were examined. Reduction in the extensor phase of convulsion was noted for the synthesized barbiturate.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.