Echinocytic red cells are present in the peripheral blood of normal human newborns in small but significant numbers. This is in contrast to normal adults in whom no echinocytes are found in peripheral blood. In addition, red cells from newborns have increased susceptibility to echinocyte transformation induced by naturally occurring phospholipid lysolecithin. The mechanism for this increased susceptibility does not appear to be related to the lipid composition of these cells. Cellular deformability of red cells from newborns, as determined by a newly developed viscodiffractometric technique, is similar to that of adult red cells. This finding differs from an earlier report of reduced deformability of fetal red cells.
The clinical features and survival rates of 112 cases of lymphosarcoma and 60 cases of reticulum cell sarcoma in children under 15 years of age, treated between 1950 and 1971, form the basis of this report. Some modifications of the Ann Arbor Classification are discussed, taking into account the local and distant dissemination of the disease and the importance of tumors arising outside the lymphatic organs. Forty of 91 Stage I and II patients, 5 of 44 Stage IVC patients, and 2 of 36 Stage IVD patients are living with a minimum followup period of 9 months. The over‐all survival rate is 27%. All deaths occurred before the 30th month following diagnosis, the survival curve not changing thereafter. A statistical analysis has been made. Age, sex, and his‐tologic type have not been found prognostically significant in this series. The initial stage has an independant significant prognostic value: The survival rate is 58% for the 54 Stage I patients, 24% for the 36 Stage II patients, and 8% for the 79 Stage IV patients. The 24 patients with non‐lymphatic forms have a 69% survival rate, as compared to 36% for the 67 patients with lymphatic forms.
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