AR h III -catalyzed strategy wasd eveloped for the rapid constructiono fh ighly substituted 2-pyridones caffolds using a,b-unsaturated oximes and fluorinated diazomalonate. The reaction proceeds through direct, site-selective alkylation based on migratory insertiona nd subsequent cyclocondensation. Awide substrate scope with different functional groups wase xplored. The requirement of fluorinated diazomalonate was explored for this transformation. The developed methodology was furthere xtended with the synthesis of the bioactive compound.Highly substituted 2-pyridones are considered as one of the most important classes of electron-deficient nitrogen-containing heterocycles due to its often occurrence as pharmaceuticals, bioactive natural products,o rganic-materials (Figure 1). [1] Since the development of classical synthetic strategies with their specific limitations, [2] transition metal catalysis played a crucial role in the development of step-economic strategies for the construction of this core. [3] Chem. Asian J. 2020, 15,360 -364
In this paper detailed investigations have been carried out through computer simulations on the reflection and transmission properties at the centre frequency of lOGHz, of 3dB Wilkinson power divider and Quadrature hybrid in microstrip form on 0.1" GaAs substrate. The simulations have been performed using simulators based on MOM and FDTD techniques.
A class of high order explicit 2-step methods for the integration of ordinary differential equations have been developed. The methods use the slopes at several auxiliary points within a step. The efficiency of the methods has been established by comparing numerical results with those of Adams-Bashforth-Moulton predictorcorrector method and Runge-Kutta fourth order method.KEY WORDS: Ordinary differential equations, initial value problems, multistep methods, hybrid methods, numerical algorithms, zero-stability, order and accuracy, numerical experiments. C. R. CATEGORY: G 1.0, G 1.7.
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