Articles you may be interested inPhase separations of single-crystal nanowires grown by self-catalytic chemical vapor deposition method Low-temperature synthesis of silica-enhanced gallium nitride nanowires on silicon substrate
Highly ordered ZnO nanowire arrays were fabricated by oxidizing the metal Zn that was electrodeposited in the pores of anodic alumina membranes (AAMs). The diameters of ZnO nanowires range from 15 to 90 nm. Atomic force microscope, x-ray diffraction, and transmission electron microscopy observations indicate the polycrystalline ZnO nanowires were uniformly assembled into the hexagonally-arranged nanochannels of the AAM. A green emission band caused by the singly ionized oxygen vacancy in the ZnO nanowires was also reported.
Glioma is one of the primary malignant brain tumours in adults, with a poor prognosis. Pharmacological reagents targeting glioma are limited to achieve the desired therapeutic effect due to the presence of blood-brain barrier (BBB). Effectively crossing the BBB and specifically targeting to the brain tumour are the major challenge for the glioma treatments. Here, we demonstrate that the well-defined small extracellular vesicles (sEVs) with dual-targeting drug delivery and cell-penetrating functions, modified by Angiopep-2 and trans-activator of transcription peptides, enable efficient and specific chemotherapy for glioma. The high efficiency of engineered sEVs in targeting BBB and glioma was assessed in both monolayer culture cells and BBB model in vitro, respectively. The observed high targeting efficiency was re-validated in subcutaneous tumour and orthotopic glioma mice models. After loading the doxorubicin into dual-modified functional sEVs, this specific dual-targeting delivery system could cross the BBB, reach the glioma, and penetrate the tumour. Such a mode of drug delivery significantly improved more than 2-fold survival time of glioma mice with very few side effects. In conclusion, utilization of the dualmodified sEVs represents a unique and efficient strategy for drug delivery, holding great promise for the treatments of central nervous system diseases.
K E Y WO R D SAngiopep-2, blood-brain barrier, dual-targeting, glioma, small extracellular vesicles, TAT
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