Medicinal plants represent the eternal kindness of almighty for the perpetuation of life in the universe. Pisonia grandis R.Br. is a flowering plant of the four O'clock family Nyctaginaceae, commonly called lettuce tree. The medicinal potential of the plant is well established and is documented by many workers. The present study is aimed to document the physiochemical parameters of the plant P. grandis reared under green house and local environment conditions. Standard methods were adopted for the physiochemical analyses. Physiochemical parameters of leaves, stem and roots of P. grandis revealed that the plant parts are a rich source of metabolites, micro and macro nutrients, minerals, fibers and proteins. Toxic metal contamination in leaves stems and roots of P. grandis are within the World Health Organization (WHO) permissible limits. All feasible documentation obtained from the current investigation makes it a wholesome record on physiochemical parameters of the folkloric medicinal plant P. grandis.
Pisonia grandis R.Br. is a rural folkloric medicinal plant of Nyctaginaceae family and has been extensively used as an anti-diabetic and antiinflammatory agent.The present study is aimed to evaluate the in-vitro anti-arthritic activity of the solvent extracts and the column fractionates of this plant. Denaturation of tissue protein is a proven cause of inflammatory and arthritic diseases. Inhibition of protein denaturation is a measure of anti arthritic activity. The petroleum-ether and ethanol extract concentrates of leaves, stems and roots of Pisonia grandis exhibited inhibition of protein denaturation. Among the extract concentrates of Pisonia grandis the non-polar extract concentrate of leaves of Pisonia grandis exhibited a 90 % inhibition of protein denaturation at 50 µg/ml concentration, comparable with that of standard drug Diclofenac sodium. The commercially well-known anti-arthritic drug palmitic acid showed 76% inhibition only at 800µg/ml. Column chromatographic analysis of petroleum ether extract of Pisonia grandis led to the isolation of stigmasterol which showed 66% inhibition of protein denaturation at 800µg/ml.
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