In bicuspid-associated aortic dilations, an asymmetric pattern of matrix protein expression was found that was consistent with the asymmetry in wall-stress distribution reported previously. Differences exist between patients with stenosis and those with regurgitation in terms of protein expression and content in the aortic wall. Further studies could clarify the relations between these findings and the pathogenesis of aortic dilatation in bicuspid aortic valve patients.

The role of particles heavier than the fluid (glass spheres in water) in a turbulent open channel flow over a smooth bed is examined at volume concentration about $10^{-3}$. The present work focuses on the dynamical interaction between the solid (particles) and the fluid phases in the near-wall region. Experimental measurements have been performed by means of phase Doppler anemometry to acquire two velocity components, particle size and concentration data simultaneously; the Reynolds number of the flow was close to 15 000. It is observed that in the particle-laden flow, the vertical profiles of the streamwise mean velocity (for both fluid and solid phases) are reduced in the outer layer ($y^{ + }\,{ >}\, 20$), but increased in the viscous sublayer ($y^{ + }\,{<}\,5$) in comparison to the clear-water conditions, leading to an apparent slip kinematic boundary condition close to the wall ($y^{ + } \,{\approx}\,2$). Moreover, in the presence of solid particles, the flow exhibits a velocity close to the wall ($y^{ + }\,{ <}\, 15$) which is smaller than that of the particles, while in the outer layer the opposite takes place. In particle-laden flow, turbulence intensities of the streamwise and especially of the vertical velocity are damped for $y^{ + }\,{>}\,10$–20 (depending on particle inertia) but enhanced in the very near-wall region ($y^{ + }\,{ <}\, 5$), as is the Reynolds stress. These findings can be explained if they are referred to the mechanism of particle entrainment and deposition, which takes place close to the wall. This mechanism is related to particle inertia and to the dynamic of the structure of near-wall turbulence, which connects the buffer and outer regions with the very near-wall region. A significant momentum exchange between the two phases, which is particularly effective in the buffer region, is revealed by the quadrant analysis of the Reynolds stresses.

Recent technological advancements have made the use of particle image velocimetry (PIV) more widespread for studying turbulent flows over a wide range of scales. Although PIV does not threaten to make obsolete more mature techniques, such as hot-wire anemometry (HWA), it is justifiably becoming an increasingly important tool for turbulence research. This paper assesses the ability of PIV to resolve all relevant scales in a classical turbulent flow, namely grid turbulence, via a comparison with theoretical predictions as well as HWA measurements. Particular attention is given to the statistical convergence of mean turbulent quantities and the spatial resolution of PIV. An analytical method is developed to quantify and correct for the effect of the finite spatial resolution of PIV measurements. While the present uncorrected PIV results largely underestimate the mean turbulent kinetic energy and energy dissipation rate, the corrected measurements agree to a close approximation with the HWA data. The transport equation for the second-order structure function in grid turbulence is used to establish the range of scales affected by the limited resolution. The results show that PIV, due to the geometry of its sensing domain, must meet slightly more stringent requirements in terms of resolution, compared with HWA, in order to provide reliable measurements in turbulence

.[1] Flows of angular rock fragments are released down a concave upward chute in the laboratory to study their mobility. This mobility is measured as the reciprocal of the apparent coefficient of friction that is equal to the vertical drop of the center of mass of the granular material divided by its horizontal distance of travel. Our experiments show that the finer the grain size (with all the other features the same), the larger the mobility of the center of mass. We believe this to be due to the fact that in finer grain size flows there are less agitated particles per unit of flow mass, so that these flows dissipate less energy per unit of travel distance. Our experiments show also that the larger the volume (with all the other features the same), the larger the apparent coefficient of friction. We believe this to be so because the frontal portion of a flow reaches the less steep part of a curved slope and stops before the rear portion, preventing the rear portion and the center of mass from traveling farther downhill. This phenomenon (which is more prominent in larger-volume flows, whose rear and frontal ends are more distant) counteracts the decrease of energy dissipation per unit of flow mass because of the decrease of particle agitation per unit of flow mass that is expected when the volume of a flow increases (with all the other features the same). Our analysis generates a functional relationship between the dimensionless apparent coefficient of friction and a scaling parameter whose numerator is equal to the mean grain size multiplied by the cube root of the deposit volume and whose denominator is the square of the channel width. The purpose of our experiments is to understand the dynamics of rock avalanches and dense pyroclastic flows.Citation: Cagnoli, B., and G. P. Romano (2012), Effects of flow volume and grain size on mobility of dry granular flows of angular rock fragments: A functional relationship of scaling parameters,

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