Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: Preliminary results

Cotrufo, Maurizio; Corte, Alessandro Della; Santo, Luca Salvatore De; Quarto, Cesare; Feo, Marisa De; Romano, G. P.; Amarelli, Cristiano; Scardone, Michelangelo; Meglio, Franca Di; Guerra, Germano; Scarano, Maria I.; Vitale, Serena; Castaldo, Clotilde; Montagnani, Stefania

doi:10.1016/j.jtcvs.2005.01.016

Cited by 126 publications

(124 citation statements)

References 23 publications

(26 reference statements)

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“…[23][24][25] The present study, however, revealed no significant change in either the adventitial or medial collagen content during TAA formation. Although this may suggest a lack of collagen degradation, given previous results establishing a temporal profile of protease production throughout TAA development, 26 it is more likely that collagen degradation and deposition remain balanced in regard to total content.…”

Section: Analysis Of Taa-induced Structural Changescontrasting

confidence: 82%

Alterations in Aortic Cellular Constituents during Thoracic Aortic Aneurysm Development

Jones

Beck

Barbour

et al. 2009

The American Journal of Pathology

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The present study tested the hypothesis that changes in the resident endogenous cellular population accompany alterations in aortic collagen and elastin content during thoracic aortic aneurysm (TAA) development in a murine model. Descending thoracic aortas were analyzed at various time points (2, 4, 8, and 16 weeks) post-TAA induction (0.5 M CaCl 2 , 15 minutes). Aortic tissue sections were subjected to histological staining and morphometric analysis for collagen and elastin, as well as immunostaining for cell-type-specific markers to quantify fibroblasts, myofibroblasts, and smoothmuscle cells. Results were compared with reference control mice processed in the same fashion. Aortic dilatation was accompanied by changes in the elastic architecture that included: a decreased number of elastic lamellae (from 6 to 4); altered area fraction of elastin (elevated at 4 weeks and decreased at 16 weeks); and a decreased area between elastic lamellae (minimum reached at 4 weeks). Total collagen content did not change over time. Increased immunoreactivity for fibroblast and myofibroblast markers was observed at 8-and 16-week post-TAA-induction, whereas immunoreactivity for smooth-muscle cell markers peaked at 4 weeks and returned to baseline by 16 weeks. Therefore, this study demonstrated that changes in aortic elastin content were accompanied by the emergence of a subset of fibroblast-derived myofibroblasts whose altered phenotype may play a significant role in TAA development through the enhancement of extracellular matrix proteolysis.

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Section: Analysis Of Taa-induced Structural Changescontrasting

confidence: 82%

Alterations in Aortic Cellular Constituents during Thoracic Aortic Aneurysm Development

Jones

Beck

Barbour

et al. 2009

The American Journal of Pathology

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“…The in vitro observed dissimilarities in proliferation and differentiation patterns in fibrosa vs. ventricularis settings could be related to regional differences in blood pressure/volume which concern the ascendant aortic wall [24]. Though these gradients do not have the same magnitude in the pulmonary circulation, a similar flow behaviour is reported for both right and left outflow tracts, where the different fluid mechanics on the ventricular vs. artery side influences the local distribution of the main ECM constituents (elastin and collagens), as well as the least represented proteins (laminin and fibronectin) [24]. In fact, the proteoglycans versican, decorin and biglycan have a significantly higher combinatorial distribution in the ventricularis with a decreasing staining intensity towards the fibrosa, while hyaluronan is strongly expressed in the spongiosa.…”

Section: Discussionmentioning

confidence: 98%

The influence of heart valve leaflet matrix characteristics on the interaction between human mesenchymal stem cells and decellularized scaffolds

Iop¹,

Renier²,

Naso³

et al. 2009

Biomaterials

106

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“…No significant differences in the contents of collagen types I, III and IV were found between the region of convexity and concavity of the aortic arch (figure 4) in the aneurysmal and control aortic wall [57]. However, another group showed that type I and III collagens were more markedly reduced in the convexity than in the concavity of the media layer of BAV-dilated ATAs with AVR [66].…”

Section: Effects Of Locationmentioning

confidence: 99%

Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review

Tsamis

Krawiec

Vorp

2013

J. R. Soc. Interface.

396

300

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Aortic disease is a significant cause of death in developed countries. The most common forms of aortic disease are aneurysm, dissection, atherosclerotic occlusion and ageing-induced stiffening. The microstructure of the aortic tissue has been studied with great interest, because alteration of the quantity and/or architecture of the connective fibres (elastin and collagen) within the aortic wall, which directly imparts elasticity and strength, can lead to the mechanical and functional changes associated with these conditions. This review article summarizes the state of the art with respect to characterization of connective fibre microstructure in the wall of the human aorta in ageing and disease, with emphasis on the ascending thoracic aorta and abdominal aorta where the most common forms of aortic disease tend to occur.

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Different patterns of extracellular matrix protein expression in the convexity and the concavity of the dilated aorta with bicuspid aortic valve: Preliminary results

Cited by 126 publications

References 23 publications

Alterations in Aortic Cellular Constituents during Thoracic Aortic Aneurysm Development

Alterations in Aortic Cellular Constituents during Thoracic Aortic Aneurysm Development

The influence of heart valve leaflet matrix characteristics on the interaction between human mesenchymal stem cells and decellularized scaffolds

Elastin and collagen fibre microstructure of the human aorta in ageing and disease: a review

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