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Introduction POSE-2 procedure shortens and narrows the stomach using multiple full-thickness plications in the gastric body. We studied the efficacy and safety of POSE-2 for obesity at 1-year in a real-world setting. Methods We reviewed the records of 75 patients who underwent POSE-2 at our unit. The primary outcome was to evaluate the %total body weight loss (%TBWL) at 1-year. Our secondary outcome was to assess the safety and durability. We used linear mixed model analysis. RESULTS: Forty-six patients completed 1-year. The rest are in various phases of follow-up. The mean(SD) age and BMI was 49.3(10.2) years and 38.2(6.6) kg/m2, respectively. The technical success rate was 98.7% (n=74). The mean(SD) TBWL, %TBWL, and the BMI decline at 1-year were 20(12.7) kg, 17.8(9.5)%, 7(4.3) kg/m2. Adverse events occurred in 4 patients. The average length of stay was 1-day. Endoscopy at 1-year in 15 patients showed intact sutures and a reduction in gastric length compared to baseline [35.7(3.5) cm vs. 26.9(5.3) cm, p<0.001] CONCLUSION: POSE-2 induced significant weight loss at 1-year. It is safe, durable and required only a short hospital stay.

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