Blood concentration and urinary excretion data demonstrated that subjects who had ingested 1 g of paracetamol after fasting overnight absorbed the drug up to 5 times more rapidly but to the same extent as when they ingested the drug after a substantial high carbohydrate breakfast. Subjects who had ingested 1 g of paracetamol immediately before sleep at night excreted up to 36% less than when they took the drug at 8.30 a.m.
The rates of rearrangement of several aminochromes have been measured in: (I) water, (2) aqueous sodium hydroxide, and (3) aqueous zinc acetate. The rates were found t o be first order with respect to aminochrome concentration in each reaction medium, and to zinc acetate concentration. However, no simple kinetic relationship between the rate of rearrangement and alkali concentration was detected. The rate increased very rapidly with increasing alkali concentration.Mechanisms for these rearrangements are suggested, based on the influence of substituents in the I-. 2-, and 3-positions of the aminochrome molecule on the kinetic and thermodvnamic features of the reaction.
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