A study of bioavailabilities and dissolution rates of commercial tablets of nitrofurantoin

McGilveray, I.J.; Mattok, G. L.; Hossie, R. D.

doi:10.1111/j.2042-7158.1971.tb08835.x

Cited by 19 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When DPH assay procedures were first developed, we found that some subjects showed consistently high plasma levels of DPH while others were consistently low (12). This is readily evident from plasma level data published recently by Remmer et al (13), shown in D ose, m g/kg Fig.…”

Section: Cp ~ (Kab-k) V [E-k (T-t|)_e Kab(t Tj)]mentioning

confidence: 51%

Panel Discussion on Case Histories in Bioavailability of Drugs

Doluisio¹,

Leeson

Glazko

et al. 1972

Pharmacology

View full text Add to dashboard Cite

Section: Cp ~ (Kab-k) V [E-k (T-t|)_e Kab(t Tj)]mentioning

confidence: 51%

Panel Discussion on Case Histories in Bioavailability of Drugs

Doluisio¹,

Leeson

Glazko

et al. 1972

Pharmacology

View full text Add to dashboard Cite

“…Five days elapsed between each dose. Complete urine collections were obtained just before and 1, 2,3,4,6,8,12, and 23 h after each dose. The volume of urine was measured and a 15 ml aliquot was immediately stored at -10'.…”

Section: Bioavailability Studymentioning

confidence: 99%

“…Urine was collected 1, 2,3,4,6,8,12, and 23 h after each dose, and nitrofurantoin was assayed by HPLC. The in vitro dissolution of the tablets was determined using USP Apparatus 1 and 2, with 0.1 N hydrochloric acid and pH 7.2 buffer as the dissolution fluids.…”

mentioning

confidence: 99%

In vitro and in vivo evaluation of seven 50 mg and 100 mg nitrofurantoin tablets

Meyer

Wood

Straughn

1989

Biopharm & Drug Disp

View full text Add to dashboard Cite

Four 50 mg and three 100 mg marketed nitrofurantoin tablets were studied in 14 healthy male subjects. Urine was collected 1, 2, 3, 4, 6, 8, 12, and 23 h after each dose, and nitrofurantoin was assayed by HPLC. The in vitro dissolution of the tablets was determined using USP Apparatus 1 and 2, with 0.1 N hydrochloric acid and pH 7.2 buffer as the dissolution fluids. One of the 50 mg tablets was more rapidly and completely absorbed than the other six products. The incidence of side-effects for this product was as low or lower than the other products. It was determined that the use of the USP Apparatus 1, at 100 rev min-1, with sampling of the pH 7.2 fluid at 30 min, provided for the best overall relationship between the urinary excretion and in vitro dissolution.

show abstract

“…However, these properties affect the dissolution rate 3 and bioavailability in humans and have been shown to influence the incidence of side effects. 4 Therefore, validation of particle sizes of bulk drug in the formulations is a very important factor for the quality of pharmaceutical preparations. A few trial evaluations of the particle size after separation of the bulk drug from the preparations have been reported.…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Mean Particle Size of Bulk Drug Powder in Pharmaceutical Preparations by Fourier-Transformed Powder Diffuse Reflectance Infrared Spectroscopy and Dissolution Kinetics

Otsuka¹,

Matsuda²

1996

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

This paper reports a quantitative correlation between specific FT-IR absorption peak intensity of phenytoin (PTH) to its particle size in the bulk as well as in powder blends. Absorption peak intensity in FT-IR spectra of phenytoin (PHT) increased with decrease of mean particle size of the powders. The relationships between the FT-IR absorbance at 1724 cm-1 of PHT and the specific surface area (Sw) obtained by the BET N2 gas absorption method or the reciprocal of mean particle size (D50) obtained by particle counting of SEM photomicrographs of ground samples showed straight lines, indicating that the absorbance followed the equation log (lo/l) = K1/D50 = K2Sw, where lo and l are intensities of the incident and transmitted light, respectively, and K1 and K2 are constants. In binary mixture of powders containing 50% PHT and 50% lactose, the relationship between the absorbance at 1724 cm-1 of PHT powder and Sw of the reciprocal of D50 also gave a linear plot. The dissolution behaviors of the binary mixture samples were measured in pH 1.2 buffer containing 0.1% sodium lauryl sulfate at 37 degrees C. The data from initial rates of dissolution of the binary mixture was utilized to calculate the particle size (Dg) using the Hixon-Crowell equation, and these particle size values were consistent with those obtained from Sw data as well as the absorbance data by the IR spectral method.

show abstract

A study of bioavailabilities and dissolution rates of commercial tablets of nitrofurantoin

Cited by 19 publications

References 2 publications

Panel Discussion on Case Histories in Bioavailability of Drugs

Panel Discussion on Case Histories in Bioavailability of Drugs

In vitro and in vivo evaluation of seven 50 mg and 100 mg nitrofurantoin tablets

Comparative Evaluation of Mean Particle Size of Bulk Drug Powder in Pharmaceutical Preparations by Fourier-Transformed Powder Diffuse Reflectance Infrared Spectroscopy and Dissolution Kinetics

Contact Info

Product

Resources

About