Acetaminophen III: Dissolution Studies of Commercial Tablets of Acetaminophen and Comparison with In Vivo Absorption Parameters

Mattok, G. L.; McGilveray, I.J.; Mainville, C.A.

doi:10.1002/jps.2600600409

Cited by 23 publications

(6 citation statements)

References 9 publications

(2 reference statements)

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“…The obtained results were in accordance with the data on cumulative urinary excretion after per oral administration of paracetamol solution reported by other authors [8,11,14] regarding both the cumulative amount excreted, as well as the time profile of the elimination; this provides further support for the hypothesis that the method described allows one to determine the total amount of paracetamol excreted (free plus conjugated).…”

Section: In Vivo Studysupporting

confidence: 91%

“…urine samples) might allow the bioavailability characteristics of different preparations to be distinguished in a rapid and easy way. Measurement of the pharmacokinetic data of paracetamol formulations using urinary excretion data has been well documented [3,7,8,[11][12][13][14] and could be achieved without the discomfort, possible hazard and necessary attendance of medical staff required for repeated venipunctures. Recently, Criado et al [15] reported a fully automated urinary screening system for paracetamol and its metabolites which comprises on-line acid microwave assisted hydrolysis of the drug to p-aminophenol followed by reaction with o-cresol in alkaline solution; the indophenol blue dye formed was monitored at 620 nm.…”

Section: Introductionmentioning

confidence: 99%

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Development of the second‐order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products

Parojčić

Karljiković‐Rajić

Đurić

et al. 2003

Biopharm & Drug Disp

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Paracetamol is a widely used nonsalicylate analgesic and antipyretic drug. The existing methods for the determination of paracetamol in biological fluids are mainly HPLC techniques, although there are some reported methods based on spectrophotometric determinations. However, all these methods involve some extraction or derivatisation procedures. In the present study the UV spectra of investigated samples were recorded over the wavelength range 220-400 nm (l step 0.21 nm; scan speed 60 nm/min) and second-order derivative spectra were calculated. Second-order derivative spectra of different blank urine samples displayed the presence of a zero-crossing point at 245-247 nm defined as l zc . The zero-order absorption spectra of paracetamol in water displays maximum absorbance at 243 nm, while in second derivative spectra, a minimum peak at 246 nm was observed. Therefore, the application of zero-crossing technique to the second-derivative UV absorption spectrum should be useful for the determination of paracetamol using 2 D lzc . The proposed method enables determination of total paracetamol in urine directly and simply by reading the 2 D lzc of the diluted samples. The obtained results were in good accordance with published data on cumulative urinary excretion after per oral administration of paracetamol obtained applying different spectrophotometric methods of determination. It could be useful for biopharmaceutical characterisation of drug products (monitoring of the levels of paracetamol in urine in bioavailability testing, for the evaluation of in vitro-in vivo correlation and screening of different formulations during drug product development).

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Section: In Vivo Studysupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Development of the second‐order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products

Parojčić

Karljiković‐Rajić

Đurić

et al. 2003

Biopharm & Drug Disp

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“…This is readily evident from plasma level data published recently by Remmer et al (13), shown in D ose, m g/kg Fig. 11.…”

Section: Cp ~ (Kab-k) V [E-k (T-t|)_e Kab(t Tj)]supporting

confidence: 65%

Panel Discussion on Case Histories in Bioavailability of Drugs

Doluisio¹,

Leeson

Glazko

et al. 1972

Pharmacology

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“…In vivo study data (3,4), but quantitative in vitro-in vivo correlations have not been demonstrated. In the present study, five commercially available immediate-release formulations of paracetamol tablets have been evaluated.…”

Section: Preparationsmentioning

confidence: 99%

An attempt to establish an in vitro-in vivo correlation: case of paracetamol immediate-release tablets

Radovanović

Đurić

Jovanović

et al. 1998

European Journal of Drug Metabolism and Pharmacokinetics

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The purpose of this study was to investigate the possibility of developing different levels of in vitro-in vivo correlation for immediate-release paracetamol tablets using in vitro dissolution data obtained under various experimental conditions. The influence of agitation intensity and pH value of the dissolution media was investigated. The level B approach, using statistical moment analysis led to poor correlation results. The results obtained by numerical deconvolution in order to study level A correlation indicated that good correlation should be sought with moderate levels of agitation (beyond 50 rpm in rotating basket apparatus). Results obtained by numerical convolution showed the highest level of correlation, level A, with one-to-one relationship between observed and predicted in vivo profiles.

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Acetaminophen III: Dissolution Studies of Commercial Tablets of Acetaminophen and Comparison with In Vivo Absorption Parameters

Cited by 23 publications

References 9 publications

Development of the second‐order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products

Development of the second‐order derivative UV spectrophotometric method for direct determination of paracetamol in urine intended for biopharmaceutical characterisation of drug products

Panel Discussion on Case Histories in Bioavailability of Drugs

An attempt to establish an in vitro-in vivo correlation: case of paracetamol immediate-release tablets

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