Background and Purpose:
Endovascular therapy for tandem occlusion strokes of the anterior circulation is an effective and safe treatment. The best treatment approach for the cervical internal carotid artery (ICA) lesion is still unknown. In this study, we aimed to compare the functional and safety outcomes between different treatment approaches for the cervical ICA lesion during endovascular therapy for acute ischemic strokes due to tandem occlusion in current clinical practice.
Methods:
Individual patients’ data were pooled from the French prospective multicenter observational ETIS (Endovascular Treatment in Ischemic Stroke) and the international TITAN (Thrombectomy in Tandem Lesions) registries. TITAN enrolled patients from January 2012 to September 2016, and ETIS from January 2013 to July 2019. Patients with acute ischemic stroke due to anterior circulation tandem occlusion who were treated with endovascular therapy were included. Patients were divided based on the cervical ICA lesion treatment into stent and no-stent groups. Outcomes were compared between the two treatment groups using propensity score methods.
Results:
A total of 603 patients were included, of whom 341 were treated with acute cervical ICA stenting. In unadjusted analysis, the stent group had higher rate of favorable outcome (90-day modified Rankin Scale score, 0–2; 57% versus 45%) and excellent outcome (90-day modified Rankin Scale score, 0–1; 40% versus 27%) compared with the no-stent group. In inverse probability of treatment weighting propensity score–adjusted analyses, stent group had higher odds of favorable outcome (adjusted odds ratio, 1.09 [95% CI, 1.01–1.19];
P
=0.036) and successful reperfusion (modified Thrombolysis in Cerebral Ischemia score, 2b-3; adjusted odds ratio, 1.19 [95% CI, 1.11–1.27];
P
<0.001). However, stent group had higher odds of any intracerebral hemorrhage (adjusted odds ratio, 1.10 [95%, 1.02–1.19];
P
=0.017) but not higher rate of symptomatic intracerebral hemorrhage or parenchymal hemorrhage type 2. Subgroup analysis demonstrated heterogeneity according to the lesion type (atherosclerosis versus dissection;
P
for heterogeneity, 0.01), and the benefit from acute carotid stenting was only observed for patients with atherosclerosis.
Conclusions:
Patients treated with acute cervical ICA stenting for tandem occlusion strokes had higher odds of 90-day favorable outcome, despite higher odds of intracerebral hemorrhage; however, most of the intracerebral hemorrhages were asymptomatic.
Objectives: To ascertain the role of CT and conventional radiographs for the initial characterization of focal bone lesions. Methods: Images from 184 patients with confirmed bone tumors included in an ethics committee-approved study were retrospectively evaluated. The reference for benign-malignant distribution was based on histological analysis and long-term follow-up. Radiographs and CT features were analyzed by 2 independent musculoskeletal radiologists blinded to the final diagnosis. Lesion margins, periosteal reaction, cortical lysis, endosteal scalloping, presence of pathologic fracture, and lesion mineralization were evaluated. Results: The benign-malignant distribution in the study population was 68.5–31.5% (126 benign and 58 malignant). In the lesions that could be seen in both radiographs and CT, the performance of these methods for the benign-malignant differentiation was similar (accuracy varying from 72.8% to 76.5%). The interobserver agreement for the overall evaluation of lesion aggressiveness was considerably increased on CT compared to radiographs (Kappa of .63 vs .22). With conventional radiographs, 18 (9.7%) and 20 (10.8%) of the lesions evaluated were not seen respectively by readers 1 and 2. Among these unseen lesions, 50%–61.1% were located in the axial skeleton. Compared to radiographs, the number of lesions with cortical lysis and endosteal scalloping was 26–34% higher with CT. Conclusion: Although radiographs remain the primary imaging tool for lesions in the peripheral skeleton, CT should be performed for axial lesions. CT imaging can assess the extent of perilesional bone lysis more precisely than radiographs with a better evaluation of lesion fracture risk.
Purpose: To study the anatomy of the latero-lateral joint (LLJ) between the upper lateral (ULC) and lower lateral (LLC) crus of the nasal cartilages, usually described as a scroll articulation.Methodology: Six nasal pyramids were taken in monobloc from fresh cadavers and imaged on micro-MRI with 0.4 mm slice thickness. Images were jointly interpreted by two head and neck radiologists and one surgeon. The junction between the ULC and LLC, the presence of ligaments and of sesamoid or accessory cartilages were assessed.Results: Eight LLJs could be analyzed, with 4 types of junctions: hook-shaped cephalic border of the LLC turned towards the nasal fossa and linear caudal border of the ULC (n=3), hook-shaped caudal border of the ULC and linear cephalic border of the LLC lateral crus (n=1), hook-shaped border of both cartilaginous edges with clinging (n=1) (scroll articulation) or without clinging (n=3). No ligament or sesamoid cartilage was found, but posterior accessory cartilages were seen in 75% of the cases.
Conclusion:The classical scroll articulation of the LLJ has been observed in only 1/8 cases on micro-MRI images. The anatomy of the LLJ couldexplain the surgical di culty in raising the tip of the nose in some patients and not in others.
Contexte: Le manque d’autonomie pour Évaluer l’impact d’un programme de formation continue destiné aux sages-femmes de salle de naissance (SF-SdN) sur les modalités de réalisation des échographies intrapartum (recours à un médecin et délais de prise en charge) ; 2) Evaluer la capacité des SF-SdN à pratiquer des échographies d’identification de la variété de position fœtale (Fetal Occiput Position – FOP) à l’issue de la formation. Méthodes : Des ateliers d’échographie d’une durée de trois heures comportant des exercices sur un simulateur de haute technologie et des cas cliniques ont été mis en œuvre dans le cadre de la formation continue des SF-SdN d’une maternité de niveau 3, de façon à former l’ensemble de l’équipe (n = 33). Une évaluation de type avant/après, sous forme d’audits permettant le recueil prospectif et systématique des échographies intrapartum (indication, identification des praticiens demandeurs et opérateurs, délai entre la décision de réaliser l’examen et la réalisation effective) a permis de quantifier l’impact de cette formation sur le nombre de recours au médecin de garde et sur les délais induits par ces recours. Pour les examens réalisés par les SF-SdN à l’issue de la formation, les proportions de FOP valides (variété de position confirmée par un second praticien) et non valides (erreur ou échec d’identification) ont été quantifiées. Résultats : Les données relatives à 72 (audit 1) et 50 échographies (audit 2) successives ont été recueillies respectivement avant et après la formation. Le nombre de recours rapporté au nombre d’examens avait significativement diminué après la formation (avant/après 80 % vs 32 % respectivement p < 0,01), les délais induits étaient également diminués (p < 0,01) avec une suppression des délais > 30 minutes pour l’audit 2 (I). La proportion de FOP valides à l’issue des ateliers était de 80 % (II). Conclusion : La formation systématique des SF-SdN à la pratique de l’échographie intrapartum permet d’optimiser les ressources en personnel (diminution des recours) et d’améliorer les soins (diminution des délais de prise en charge). L’utilisation large de la simulation dans ce cadre pourrait permettre de garantir la présence d’un praticien formé à l’échographie à proximité immédiate de toute patiente en travail.
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