Pyoderma gangrenosum (PG) is an uncommon neutrophilic dermatosis which may be associated with systemic disorders. Approximately 50% of patients with PG have an associated systemic disease. It's most associated with inflammatory bowel disease, inflammatory arthritis, and hematological disorders. Bullous PG is rare type of PG and is mostly reported in patients with comorbid myeloproliferative diseases. We present a case of bullous PG who was diagnosed with myelodysplastic syndrome.