Sickle-cell anaemia, together with other' genetically determined haemoglobinopathies, is becoming an increasingly important cause of childhood mortality in the tropics as deaths from other tropical diseases steadily decrease in number. So far no treatment has been of any avail, and the only supportive measure of any real value during a crisis has been blood transfusion. Recently, however, it has been suggested that acetazolamide (" diamox") might be a valuable therapeutic agent, since it acts as a carbonic anhydrase inhibitor and was shown in one case to diminish intravascular sickling (Hilkovitz, 1957). We would therefore like to record our experiences of the use of. this drug in three children, with' sickle-cell anaemia admitted to King George VI Hospital, Nairobi. Case Reports Case 1.-A child age 3 months was admitted with a chest infection and diarrhoea. The haemoglobin was 6.1 g./
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