A Study of the Survival Rate of Cases of Sickle-cell Anaemia

Jacob, G. F.

doi:10.1136/bmj.1.5021.738

Cited by 17 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is important that different regions and both rural and urban populations be represented. The frequency of survival among African children born with SCD appears to be highly variable by time and place, consistent with observations made by Jacob 34 more than 50 years ago. The probability of early death among children born with SS in sub-Saharan Africa might be as high as 90% in rural areas where access to health care is limited, but closer to 50% in populations with better access to health care and lower exposure to infectious diseases.…”

Section: Resultssupporting

confidence: 88%

Sickle Cell Disease in Africa

Grosse

Odame

Atrash

et al. 2011

American Journal of Preventive Medicine

512

272

View full text Add to dashboard Cite

Sickle cell disease (SCD) is common throughout much of sub-Saharan Africa, affecting up to 3% of births in some parts of the continent. Nevertheless, it remains a low priority for many health ministries. The most common form of SCD is caused by homozygosity for the β-globin S gene mutation (SS disease). It is widely believed that this condition is associated with very high child mortality, but reliable contemporary data are lacking. We have reviewed available African data on mortality associated with SS disease from published and unpublished sources, with an emphasis on two types of studies: cross-sectional population surveys and cohort studies. We have concluded that, although current data are inadequate to support definitive statements, they are consistent with an early-life mortality of 50%–90% among children born in Africa with SS disease. Inclusion of SCD interventions in child survival policies and programs in Africa could benefit from more precise estimates of numbers of deaths among children with SCD. A simple, representative, and affordable approach to estimate SCD child mortality is to test blood specimens already collected through large population surveys targeting conditions such as HIV, malaria, and malnutrition, and covering children of varying ages. Thus, although there is enough evidence to justify investments in screening, prophylaxis, and treatment for African children with SCD, better data are needed to estimate the numbers of child deaths preventable by such interventions and their cost effectiveness.

show abstract

Section: Resultssupporting

confidence: 88%

Sickle Cell Disease in Africa

Grosse

Odame

Atrash

et al. 2011

American Journal of Preventive Medicine

512

272

View full text Add to dashboard Cite

show abstract

“…However, in general the prognosis is not favorable and, in Africa, the mortality in early childhood is high. [1][2][3][4] In addition to the medical problems themselves, the social and psychologic aspects of the disease place chronic strains on the patient and his family.…”

mentioning

confidence: 99%

Some Social-Psychologic Dimensions of Sickle Cell Anemia Among Nigerians

Bamisaiye

Bakare

Olatawura

1974

Clin Pediatr (Phila)

View full text Add to dashboard Cite

“…vaccine in five patients with Haemoglobin AS and one patient with sickle-cell thalassaemia. In Uganda and the Congo the early childhood mortality is known to be high in sickle-cell anaemia (Lambotte-Legrande and Lambotte-Legrande, 1955 ;Jacob, 1957 ;Trowell et al, 1957).…”

mentioning

confidence: 99%