The analysis of 182 selected anti‐B cell sera on 102 cells allowed us to identifysseveral clusters of sera. They showed no correlation with HLA‐A, B or C specificities but many associations with the HLA‐D determinants. In 10 families, most of these sera segregated with HLA, and five recombinants showed a linkage with the BD or D end part of the MHC. The panel distribution and the family analysis indicated that at least one (the Ly‐Li system) and probably two segregant series could exist close to the HLA‐D locus.
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