Joint Report of the B Lymphocyte Specificities Workshop of the France‐one Region by FRANCE‐ONE with the collaboration of

The intensity of the primary mixed lymphocyte reaction (MLR) seems to be influenced by at least two distinct determinants of the HLA-D region: the HLA-Dw stimulating products and the human Ia-like B lymphocyte DR (D-related) antigens. In three families, the primary MLR is significantly higher in case of HLA haploidentity, when stimulating and responding cells differ with regard to both Dw and DRw determinants, than when only Dw products are different. Thus, an additional effect of DR antigens during primary MLR is observed. The role of DRw antigens in primary MLR and the results obtained by a primed lymphocyte test which can discriminate between Dw3 and DRw3, indicate that DRw and Dw products could be distinct determinants.

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Human Ia‐like DRw lymphocyte antigens stimulating activity in primary mixed lymphocyte reaction

Fradelizi

Núñez‐Roldán

Sasportes

1978

Eur J Immunol

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Analysis of products involved in primary and secondary allogenic proliferation in man

1978

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Interferon inhibits the generation of allospecific suppressor T lymphocytes.

Fradelizi¹,

Gresser²

1982

The Journal of Experimental Medicine

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The effect of human interferon alpha on the differentiation of functional populations of lymphocytes during the human allogeneic response in vitro was studied. Interferon alpha inhibited the generation of allospecific suppressor T lymphocytes that normally develop from lymphocytes primed in vitro against allogeneic cells. This effect was not the result of the destruction by interferon of precursor suppressor cells but rather to inhibition of their differentiation into active suppressor T lymphocytes. This inhibition was reversible and could be overcome by repeated allogeneic stimulation even in the presence of interferon. Inhibition of the generation of allospecific suppressor lymphocytes by interferon might play an important role in the allogeneic response. Interferon inhibited the proliferation of lymphocytes after allogeneic stimulation in a primary mixed lymphocyte reaction but enhanced their cytotoxicity. Despite the inhibitory effect in the primary mixed lymphocyte reaction, the specific secondary proliferative response of lymphocytes primed against a single HLA-DR antigen was only slightly affected by interferon. On the other hand, the nonspecific secondary proliferative response of lymphocytes primed in the presence of interferon was significantly reduced, indicating that interferon might decrease the recruitment of nonspecific "irrelevant" clones of responding cells during the sensitization period.

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Joint Report of the B Lymphocyte Specificities Workshop of the France‐one Region by FRANCE‐ONE with the collaboration of

Cited by 7 publications

References 10 publications

Human Ia‐like DRw lymphocyte antigens stimulating activity in primary mixed lymphocyte reaction

Human Ia‐like DRw lymphocyte antigens stimulating activity in primary mixed lymphocyte reaction

Analysis of products involved in primary and secondary allogenic proliferation in man

Interferon inhibits the generation of allospecific suppressor T lymphocytes.

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