We have studied changes in the IGF axis in an ovine model of myocardial infarction (MI), in order to determine the relationship between time-based changes in postinfarct myocardium and IGF levels. IGF localization was studied by immunocytochemistry, production by in situ hybridization, and specific binding by radioligand studies.

SHeart, Lung and Circulation S145 2010;19S:S1-S268 Abstracts the Amplatzer PFO occlusion device during the same period. Methods: We performed a retrospective review of all patients undergoing percutaneous device closure using the Premere or Amplatzer PFO occlusion device between July 2006 and November 2009.Results: A total of patients 73 (60.3% male) underwent device closure (Premere; n = 28) during the study period. Complete follow up data was available in 79.5%. The mean age of those undergoing closure was 47.3 ± 14.1 years. The indication for closure was stroke/TIA in 83.6% with the remainder treated for migraine, other paradoxical embolus or hypoxaemia complicating right to left intracardiac shunting. Immediate procedural success was obtained in 95.9%. Procedural fluoroscopy duration was 6:08 ± 4:34 min using the Amplatzer occluder compared with 8:31 ± 3:30 min using the Premere occluder. Echocardiography obtained a mean of 6.1 months after the procedure confirmed defect closure in 82.6%.Conclusions: Premere and Amplatzer PFO occlusion devices offer similar immediate procedural results with successful defect closure confirmed. Procedural duration was lower in the Amplatzer group, likely due to the ability to perform the procedure under local anaesthesia without transoesophageal guidance.

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