A low-molecular-weight, sugar-like compound other than glucose, fructose, sucrose, or myo-inositol showing lipophilic nature was isolated from the EtOH extract of Acacia nilotica. The structure of the compound was determined by spectral methods. This alicyclic polyalcohol was found to be D-pinitol (= 3-O-methyl-D-chiro-inositol; 1). The configuration of the compound was confirmed by single-crystal X-ray analysis. The compound 1 is known from Soybean, Australian mangroves, Fagonia indica, Arachis hypogaea, etc., but we have isolated this compound for the first time from the aerial parts of A. nilotica. Very few references have been cited for compound 1 for its entomological activity, and there are no reports on mosquitoes. Therefore, the crude extracts of A. nilotica were tested for its biological activity against mosquito larvae. Acetone extract at 500-ppm concentration showed chronic toxicity against Aedes aegypti and Culex quinquefasciatus IVth instar mosquito larvae. Such a biological activity has been observed for the first time for this plant. This study could be a stepping stone to a solution for destroying larval species as well as consumption of such a widely grown, problem weed, A. nilotica. This larvicidal agent, since it is derived from plant, is eco-friendly, cost effective, non-hazardous to non-target organisms and would be safe unlike commercially available insecticides.
Alkylation of various β-ketoesters IIIa - d with bis(p-methoxycarbonylphenyl)bromomethane (II) and bis(p-chlorophenyl)bromomethane (VI) followed by cleavage of ethoxycarbonyl group or hydrolysis and esterification gave methoxycarbonylphenyl and chlorophenyl analogues of ar-juvabione, respectively. Condensation of bis(p-methoxycarbonylphenyl)methanol (IX) with isovaleryl and trichloroacetyl chloride gave isovalerate X and trichloroacetate XI, respectively, while the condensation of bis(p-chlorophenyl)methanol (XII) with isovaleryl chloride and citronellyl bromide yielded isovalerate XIII and citronellyl ether XIV, respectively. The methoxycarbonylation of aryl-alkyl ketones XVa - d with oxalyl chloride and treatment with methanol furnished various ar-juvabione analogues XVIa - d. The compounds Vb, Vc, Vd, XVIb, and XVIc showed high activity against Dysdercus koenigii at 1μg concentration.
Products Active on Mosquitoes. Part 7. Synthesis and Biological Activity of Longifolene Derivatives. -The title compounds, e.g. (I) and (II), are prepared by conventional procedures and their biological activity is evaluated on eggs and larvae of mosquito Culex quinquefasciatus. The most promising derivative (IIa) is 20 times less active than methoprene. -(SAWAIKAR, D. D.; SINHA, B.; HEBBALKAR, G. D.; SHARMA, R. N.; PATWARDHAN, S. A.; Indian J.
Synthesis and Biological Activity of Aromatic Terpenoid OximeEthers.-A series of aromatic terpenoid oxime ethers (39 examples) are prepared and examined for biological activity. -(SURESH, S.; PADALKAR, S. N.; JOSHI, U. M.; JOSEPH, M.; PAWAR, P. V.; HEBBALKAR, G. D.; TUNGIKAR, V. B.; SHARMA, R. N.; PATWARDHAN, S. A.; Indian J.
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