The synthesis of the new dihydropyridine diethyl 1,4‐dihydro‐4‐(imidazo[1,5‐α]pyridin‐8‐yl)‐2,6‐dimethyl‐pyridine‐3,5‐dicarboxylate (1) is described. After many attempts to prepare the key intermediate aldehyde 2a by different approaches, this compound has been obtained in good yields from methyl 2‐cyano‐3‐pyridinecar‐boxylate (10). A three‐step procedure involving reduction to the amine, formylation with concomitant cyclization and reduction of the ester group was used.
Imidazol-1-yl and Pyridin-3-yl Derivatives of 4-Phenyl-1,4-dihydropyridines Combining Ca2+ Antagonism and Thromboxane A2 Synthase Inhibition. -The synthesis of a series of compounds combining significant Ca2+-antagonism and thromboxane A2 synthase inhibition in the same molecule is described. The title compounds (I) are investigated in vitro in whole rat blood during clotting and in guinea-pig ileum strips. Especially, compound (Ib) is found to be of high activity in both fields of application. -(COZZI, P.; CARGANICO, G.; FUSAR, D.; GROSSONI, M.; MENICHINCHERI, M.; PINCIROLI, V.; TONANI, R.; VAGHI, F.; SALVATI, P.; J.
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
N-Imidazolyl Derivatives of the Naphthalene and Chroman Rings as Thromboxane A2 Synthase Inhibitors.-Nearly 30 examples of title compounds such as (II)-(V) are mainly synthesized as outlined in the scheme and tested for their activities. Some structural requirements for significant thromboxane A2 synthase inhibitory activity are discussed. On the basis of its low toxicity the derivative (IIa) is selected for clinical investigations. -(COZZI, P.; BRANZOLI, U.; CARGANICO, G.; FERTI, C.; PILLAN, A.; SEVERINO, D.; TONANI, R.; Eur.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.