In the last decades, inositols attracted a growing interest since the acknowledgement of their role in insulin-activated signalling pathways. Myo-inositol (MI) and D-Chiro Inositol (DCI) are the most important isoforms and their use as insulin-sensitizer in treatment of polycystic ovarian syndrome is well known. New discoveries have paved the way for a wide range of new applications. For this reason, we collected the most interesting ideas and updates regarding inositols therapy to reason on innovative uses, with a particular focus in the field of infertility. We reviewed recent literature on inositol with a particular focus in the field of ovarian function and infertility. Recent researches on inositols are focusing on different signalling pathways other than the insulin-sensitizing one, such as inflammation signalling or androgens modulation. Furthermore, MI and DCI act in different ways and dosage and ratio seem to have different effects in different organs. Indeed, the use of inositols is developing promisingly in situations other than the treatment of insulin resistance and this is opening up new perspectives for increasingly personalized and effective therapies.
Introduction: Sacral neuromodulation (SNM) is a technique that electrically stimulates the third sacral spinal nerve root to modulate a neural pathway. In this study, we present our 7-years ' experience outcomes and complications of SNM in lower urinary tract dysfunctions. Methods:We performed a single-center retrospective cohort study of all patients who underwent InterStim Medtronic SNM device implantation for lower urinary tract dysfunction. All procedures were performed between January 2014 and November 2021 in the Urogynecologycal Center of Villa Sofia Hospital in Palermo by a single expert team. We included 68 patients with refractory lower urinary tract dysfunction who did not adequately respond to primary therapeutical strategies. Results:We observed a reduction rate of catheterization from a mean of 4.05 to 1.22. In addition, the amount of post-voidal residual decreased from a mean of 520 ml to 187 ml. Among the 41 women in the overactive bladder group, only 36 were included in the follow-up; 24 of the 36 patients (66.6%) had no episodes of leaks; the remaining patients (33.4%) had a significant reduction of leaks. We also recorded a significant reduction in urinary frequency: voids per day decreased from 16.1 at baseline to 6.1. Among the 7 women with BPS, only 5 patients (71.42%) completed the follow-up protocol. They reported satisfaction from the treatment: no patients chronically used pain drugs, and only 1 used occasionally painkillers. Conclusion:SNM treatment has been found as a potential effective and feasible option for urogynecologycal disorders.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.