Inositols administration: further insights on their biological role

Coldebella, D.; Buzzaccarini, G.; Ferrari, J.; Sleiman, Z.; D’Alterio, M.N.; Corte, L. Della; Cucinella, G.; Gullo, G.

doi:10.36129/jog.2022.40

Cited by 8 publications

(4 citation statements)

References 56 publications

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“…Nutraceutical supplementation with inositols, alpha-lipoic acid, vitamin D, and metformin may hold promise in reducing the risk of GD in PCOS patients, although further research is needed to confirm their efficacy. We can benefit from the growing literature addressing clinical improvement of patient care [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Maternal Diabetes Mellitus and Neonatal Outcomes in Bisha: A Retrospective Cohort Study

Alshomrany,

Miskeen,

Alfaifi

et al. 2024

Medical Sciences

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Background: Maternal diabetes mellitus (MDM) is associated with increased risks for adverse neonatal outcomes. However, the impact of MDM on neonatal outcomes in Bisha, a city in Saudi Arabia, is not well documented. This study aims to investigate the impact of MDM on neonatal outcomes in the Maternity and Children’s Hospital (MCH), Bisha, Saudi Arabia. Methods: A retrospective cohort study was conducted on 181 pregnant women with diabetes and their neonates who were diagnosed at the Maternity and Children’s Hospital (MCH), Bisha, Saudi Arabia, between 5 October 2020 and 5 November 2022. The primary outcome was a composite of adverse neonatal outcomes, including stillbirth, neonatal death, macrosomia, preterm birth, respiratory distress syndrome, hypoglycemia, and congenital anomalies. Logistic regression analyses were used to adjust for potential confounders. Results: The total sample size was 181. The average age of patients was 34 years (SD = 6.45). The majority of the patients were diagnosed with GDM, 147 (81.2%), and pre-GDM, 34 (18.8%). Neonates born to mothers with MDM had a higher risk of adverse neonatal outcomes compared to those born to mothers without MDM (adjusted odds ratio [aOR] = 1.46, 95% confidence interval [CI]: 1.25–1.70). The risks of macrosomia (aOR = 1.74, 95% CI: 1.38–2.19), LBW (aOR = 1.32, 95% CI: 1.06–1.66), and RDS (aOR = 1.57, 95% CI: 1.28–1.93) were significantly higher among neonates born to mothers with MDM. The types of DM were statistically significant in terms of their correlation with the following neonatal outcomes: hypoglycemia (p-value = 0.017), macrosomia (p-value = 0.050), and neonatal death (p-value = 0.017). Conclusions: MDM is associated with an increased risk of adverse neonatal outcomes in Bisha. The early identification and management of MDM may improve neonatal outcomes and reduce the burden of neonatal morbidity and mortality in this population.

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Section: Discussionmentioning

confidence: 99%

Maternal Diabetes Mellitus and Neonatal Outcomes in Bisha: A Retrospective Cohort Study

Alshomrany,

Miskeen,

Alfaifi

et al. 2024

Medical Sciences

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“…It is worth mentioning that chronic anovulation is one of the most important causes of female infertility. The possible treatment of this condition was reported by some natraceutical supplementations such as D-chiro-inositol and Myo-inositol [ 27 , 28 ]. It is also crucial to analyze neonatal outcomes and long-term follow-up of children born from assisted reproductive technologies (ART).…”

Section: Discussionmentioning

confidence: 99%

Thyroid hormones and ovarian reserve: a comprehensive study of women seeking infertility care

Halici,

Seker,

Gebedek

et al. 2023

BMC Women's Health

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Background Ovarian reserve is the number of oocytes remaining in the ovary and is one of the most important aspects of a woman’s reproductive potential. Research on the association between thyroid dysfunction and ovarian reserve has yielded controversial results. In our study, we aimed to investigate the relationship between thyroid-stimulating hormone (TSH) levels and ovarian reserve markers. Methods From 1443 women seeking infertility care, the data of 1396 women aged between 20–45 years old who had a body mass index between 18–30 kg/m2 were recruited for this retrospective study. The anti-Müllerian hormone (AMH) and TSH relationship was analyzed with generalized linear and polynomial regression. Results Median age, follicle-stimulating hormone (FSH), AMH, and TSH levels were 36.79 years, 9.55 IU/L, 3.57 pmol/L, and 1.80 mIU/L, respectively. Differences between TSH groups were statistically significant in terms of AMH level, antral follicle count (AFC), and age (p = 0.007 and p = 0.038, respectively). A generalized linear regression model could not explain age-matched TSH levels concerning AMH levels (p > 0.05). TSH levels were utilized in polynomial regression models of AMH, and the 2nd degree was found to have the best fit. The inflection point of the model was 2.88 mIU/L. Conclusions Our study shows a correlation between TSH and AMH values in a population of infertile women. Our results are as follows: a TSH value of 2.88 mIU/L yields the highest AMH result. It was also found that AMH and AFC were positively correlated, while AMH and FSH were negatively correlated.

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“…MI can be also endogenously produced in the human kidney and liver from glucose-6-phosphate in just two reactions. The first one is catalyzed by MI-1-phosphate synthase (MIPS) and the second one by inositol monophosphatase-1 (IMPase) (Figure 1) [19][20][21]. To date, no dietary requirements regarding the amount of inositol daily intake have been established for humans.…”

Section: Sources and Metabolism Of MImentioning

confidence: 99%

Cyclitols: From Basic Understanding to Their Association with Neurodegeneration

et al. 2023

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One of the most common cyclitols found in eukaryotic cells—Myo-inositol (MI) and its derivatives play a key role in many cellular processes such as ion channel physiology, signal transduction, phosphate storage, cell wall formation, membrane biogenesis and osmoregulation. The aim of this paper is to characterize the possibility of neurodegenerative disorders treatment using MI and the research of other therapeutic methods linked to MI’s derivatives. Based on the reviewed literature the researchers focus on the most common neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and Spinocerebellar ataxias, but there are also works describing other seldom encountered diseases. The use of MI, d-pinitol and other methods altering MI’s metabolism, although research on this topic has been conducted for years, still needs much closer examination. The dietary supplementation of MI shows a promising effect on the treatment of neurodegenerative disorders and can be of great help in alleviating the accompanying depressive symptoms.

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Inositols administration: further insights on their biological role

Cited by 8 publications

References 56 publications

Maternal Diabetes Mellitus and Neonatal Outcomes in Bisha: A Retrospective Cohort Study

Maternal Diabetes Mellitus and Neonatal Outcomes in Bisha: A Retrospective Cohort Study

Thyroid hormones and ovarian reserve: a comprehensive study of women seeking infertility care

Cyclitols: From Basic Understanding to Their Association with Neurodegeneration

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