the volume of the heart is small. The vasomotor responses are therefore inadequate. The blood pressure and pulse response to standard exertion lags. The two-step exercise electrocardio¬ gram may be abnormal. Thus, on exertion they have a func¬ tional coronary insufficiency which -is probably neurogenic.
Oral propylenglycol is able to lower intraocular pressure through an osmotic mechanism of action both in eyes suffering from different forms of :glaucoma and in normal eyes. The dosage employed to obtain an effective reduction in intraocular pressure is 1.5 g./Kg of body weight. Duration of the tension-lowering effect is about 5 hours in most cases treated. The drop in pressure varied with the height of the pressure at the time therapy began -the higher the initial pressure, the greater the fall. The response varied with the strength of the dosages employed.Oral propylenglycol has proven particularly useful in longterm treatment of glaucomatous patients with diabetes, as it does not alter significantly blood sugar levels. The drug was fairly well tolerated and side-effects, such as ]headache, nausea, diarrhea and thirst were never reported. Only some patients complained of slight dizziness. The topical application of an ointment composed of propylenglycol has proven effective in clearing the cornea in 8 patients suffering from corneal edema of various origin, sometimes accompanied by bullous keratopathy.
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