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19) Epstein, L. M.; Straub, D. K.; Maricondi, C. Inorg. Chem. 1967, 6, 1720-1724. (20) Brunori, M.; Giacometti, G. M.; Antonini, E.; Wyman, J. 1231.(26) The optical spectra show that although K2 is small but finite, for purposes of the analysis of kinetic data we may i nore the binding of the second base. The linear dependence of k w on [CO? and its simultaneous independence of [Im-] show that loss of base and subsequent CO binding contribute minimally compared with direct CO addition to the five-coordinate species.Abstract: L-(8S)-Arogenate (previously named pretyrosine), a newly recognized precursor of L-phenylalanine and L-tyrosine biosynthesis, is widely distributed in nature. Proof of structure for arogenate, 0-( I-carboxy-4-hydroxy-2,5-cyclohexadien-lyl)alanine, was established through the application of spectroscopic techniques (ultraviolet, 'H NMR, I3C NMR, and mass spectrometry) following the application of an improved procedure for isolation of L-arogenate from the culture supernatant of a mutant strain of Neurospora crassa. The ( S ) configuration of the chiral amino acid carbon at C-8 of L-arogenate was established by circular dichroism.

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