The tremorgenic mycotoxins isolated from Aspergillus terreus were given the trivial names territrem A and territrem B instead of their previous designations of C, and C2, respectively. High-resolution mass spectral data suggested the molecular formula of territrem A to be C2sHaoO9 and that of territrem B, C29H3409.
Propargylamines are valuable molecules in medicinal chemistry and organic synthesis. A 3 reaction is straightforward access to construct propargylamine and its derivatives. Here we report operationally simple catalytic domino A 3 -coupling/aza-Michael addition of a primary amine, formaldehyde solution, an alkyne, and an olefin using copper as a catalyst to produce a series of functionalized propargylamines in moderate to excellent yields. This protocol involves a competition between aza-Michael addition and Mannich reaction. By changing the amount loading of amines to control the process of Mannich reaction is the key procedure of increasing the selectivity.
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