Territrems, tremorgenic mycotoxins of Aspergillus terreus

Abstract

The tremorgenic mycotoxins isolated from Aspergillus terreus were given the trivial names territrem A and territrem B instead of their previous designations of C, and C2, respectively. High-resolution mass spectral data suggested the molecular formula of territrem A to be C2sHaoO9 and that of territrem B, C29H3409.

Solvent systems for improved isolation and separation of territrems A and B

“…The coefficient of variance in yield from five batches was 12%. Each pure toxin showed the same properties as previously reported (5).…”

“…The discovery of territrem-producing strains of A. terreus was initiated by Ling and his coworkers, starting from a mycological survey of aflatoxin-producing fungi. Consequently, the initial procedures for cultivation of A. terreus 23-1 and the subsequent purification of territrems were similar to those for aflatoxins (5,9). When the natural substrates served as cultural media of aflatoxins, difficulties arose from (i) interfering components in the crude extracts, (ii) close similarity of the chemical structures, and (iii) great relative differences in the amounts of each toxin (7).…”

“…Territrem A (C28H3009) and territrem B (C29H3409) are new tremorgenic mycotoxins isolated from the rice culture of Aspergillus terreus (5). The structure of territrem B (Fig.…”

Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem B' from Aspergillus terreus

“…A series of structurally related tremorgenic metabolites, designated territrems A, B, and C (TRA, TRB, and TRC, respectively), was isolated from the chloroform extract of a rice culture of Aspergillus terreus 23-1 (2,4). Recently, we have succeeded in isolating another related metabolite from the condensed fraction I of the chloroform extract of the same rice culture.…”

“…The procedures for analysis of some physicochemical properties of TRB' were followed as described previously (4). High-resolution mass spectra were analyzed with an AEI MS-30 spectrometer (Shrader Analytical Consulting Laboratories Inc., Detroit, Mich.).…”