pCR is associated with better outcome regardless of HR status in breast cancer patients who receive PC.

No abstract

Objectives To determine the characteristics of popular breast cancer related websites and whether more popular sites are of higher quality. Design The search engine Google was used to generate a list of websites about breast cancer. Google ranks search results by measures of link popularity-the number of links to a site from other sites. The top 200 sites returned in response to the query "breast cancer" were divided into "more popular" and "less popular" subgroups by three different measures of link popularity: Google rank and number of links reported independently by Google and by AltaVista (another search engine). Main outcome measures Type and quality of content. Results More popular sites according to Google rank were more likely than less popular ones to contain information on ongoing clinical trials (27% v 12%, P = 0.01 ), results of trials (12% v 3%, P = 0.02), and opportunities for psychosocial adjustment (48% v 23%, P < 0.01). These characteristics were also associated with higher number of links as reported by Google and AltaVista. More popular sites by number of linking sites were also more likely to provide updates on other breast cancer research, information on legislation and advocacy, and a message board service. Measures of quality such as display of authorship, attribution or references, currency of information, and disclosure did not differ between groups. Conclusions Popularity of websites is associated with type rather than quality of content. Sites that include content correlated with popularity may best meet the public's desire for information about breast cancer.

The likelihood of positive NSLNs correlates with primary tumor size, size of the largest SLN metastasis, and presence of lymphovascular invasion. A scoring system incorporating these factors may help determine which patients would benefit from additional axillary surgery.

No abstract

BACKGROUND To distinguish true local recurrences (TR) from new primary tumors (NP) and to assess whether this distinction has prognostic value in patients who develop ipsilateral breast tumor recurrences (IBTR) after breast‐conserving surgery and radiotherapy. METHODS Between 1970 and 1994, 1339 patients underwent breast‐conserving surgery at The University of Texas M. D. Anderson Cancer Center for ductal carcinoma in situ or invasive carcinoma. Of these patients, 139 (10.4%) had an IBTR as the first site of failure. For the 126 patients with clinical data available for retrospective review, we classified the IBTR as a TR if it was located within 3 cm of the primary tumor bed and was of the same histologic subtype. All other IBTRs were designated NP. RESULTS Of the 126 patients, 48 (38%) patients were classified as NP and 78 (62%) as TR. Mean time to disease recurrence was 7.3 years for NP versus 5.6 years for TR (P = 0.0669). The patients with NP had improved 10‐year rates of overall survival (NP 77% vs. TR 46%, P = 0.0002), cause‐specific survival (NP 83% vs. TR 49%, P = 0.0001), and distant disease‐free survival (NP 77% vs. TR 26%, P < 0.0001). Patients with NP more often developed contralateral breast carcinoma (10‐year rate: NP 29% vs. TR 8%, P = 0.0043), but were less likely to develop a second local recurrence after salvage treatment of the first IBTR (NP 2% vs. TR 18%, P = 0.008). CONCLUSIONS Patients with NP had significantly better survival rates than those with TR, but were more likely to develop contralateral breast carcinoma. Distinguishing new breast carcinomas from local disease recurrences may have importance in therapeutic decisions and chemoprevention strategies. This is because patients with new carcinomas had significantly lower rates of metastasis than those with local disease recurrence, but were more likely to develop contralateral breast carcinomas. Cancer 2002;95:2059–67. © 2002 American Cancer Society. DOI 10.1002/cncr.10952

Oberflächenchemie: Eine durch thermische Oxidation und Nitrierung hergestellte Ta3N5‐Photoanode zeigt den höchsten bisher mit einer Ta3N5‐Photoanode erreichten Photostrom. Dieser Photostrom entsteht hauptsächlich als Folge des leichten thermischen und mechanischen Abblätterns der passivierenden Oberflächenschicht von der Ta3N5‐Photoanode (siehe Bild).

Breast-conservation surgery plus radiotherapy was associated with grade 2 or higher complications in only 9.9% of patients. Half of these complications were attributable to axillary dissection, it is hoped that lower complication rates can be achieved with sentinel lymph node biopsy. Breast-conservation surgery and radiotherapy is associated with grade 2 or greater complications in only 9.9% of patients. Nearly half of these complications are attributable to axillary dissection.