In this experiment, the effect of excessive exercise on the sexual cycle and histological changes of various organs of albino rats were observed. Of the sexual cycle of albino rats Gotoda (1) found that the fatigue caused by vibration brings about a considerable prolongation of the anestrus period. Hirai (2) made a comparative histological study on the myocard and skeletal muscle of animals which habitually move actively and those which do not move so much.Ogawa (3) made albino rats swin and measured changes in the weight of the principal organs.Selye (4, 5) investigated histological changes in each stage of stress reaction and reported that the hypersecretion of the adrenal cortical hormone and pituitary ACTH, hemorrhagic ulcer in stomach and intestine, nodular myocarditis, perivasculitis, abnormal swelling of renal tubuli and the degenerative change of thymus could be seen. METHODExperiments were made on albino rats weighing 120-150g. using a method requiring forced swimming in a tank.Tests were made in the following three groups:A group (excessively trained):trained for 60 or over 90 days. B group (castrated and excessively trained):4 weeks after castration, 60 days training was applied. C group (untrained):untrained rats were forced-swum. For the test of the sexual cycle, 36 rats were selected whose sexual cycle (vaginal smear method) were comparatively regular. At first they were given light exercise of 10-30 minutes swimming and gradually the time was extended and by 17 days the training lasted 3-6 hours daily.The vaginal smear was examined before the exercise and if deemed necessary several times a day at an interval of two hours.The sexual cycle was divided into 4 phases according to Zondek and Aschheim; prestrus (P), estrus (E), metestrus (M) and diestrus (D).Histological changes in various organs were observed under ordinary staining, but according to necessity the fat, hemosiderin and calcium were examined under special staining.
Some mental friction or sensory stimulation may put animals to peculiar movements or attitudes which are called experimental neurosis. On this subject numerous reports have been made since Maier (1, 1939). In experimental neurosis the loss or weakening of various reflexes is common. Hiwatari (3) found a deviation of eye balls due to the loss of rapid. phase and the remaining of slow phase of the rotatory nystagmus and he attributed this to the disturbances in cerebral cortex and brain stem. EEG, EMG and ECG in experimental neurosis were studies by Lindsley (5), Hiwatari and Tsukiyama (3) and recently by Sugi (9). Regarding the temperature of skin and brain during seizure, experiments were made by Sasaki (6) and these results were summulized by Yoshii (7). Authors have come to know that if an excessive exercise is applied repeatedly to albino rats, similar symptoms as those of experimental neurosis may occur. This should be called "Training seizure". Beside the observation of the symptoms of this seizure, investigations were made on changes in the weight of brain and the brain content of K and Na and also histological changes in the central nervous system.
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