Kinetic and thermodynamic parameters of alcoholysis reactions have been carefully studied by gas chromatography. The methanolysis of diethyl acetal was studied by Juvet and Chiu (1) and later modified as a gas chromatography experiment for determination of the rate constants for the two-step reaction (2). Juvet and Wachi (3) reported equilibrium constants for the alcoholysis of propionate and butyrate esters, and estimated the precision of the gas chromatographic method to be about 1-2%. Rowland et al. (J, 5) extensively studied malonate transesterifications and provided kinetic, equilibrium thermodynamic, and mechanistic information; Johnson et al. ( 6) carefully studied the kinetics of the methanolysis of diethyl malonates. The application of binomial statistics to the chemical systems herein described is in many respects analagous to the recently developed theory of electron transfer with reactants having multiple electroactive centers (7).
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